Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 20/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 20/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 19/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7213199 | 0.86 | ADRA1A (0.63) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7213122 | 0.81 | ADRA1A (0.59) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7212032 | 0.80 | ADRA1A (0.54) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7747425 | 0.80 | ADRA1A (0.49) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7747511 | 0.78 | ADRA1A (0.57) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7747513 | 0.78 | ADRA1A (0.57) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL7748916 | 0.78 | ADRA1A (0.67) | ADRA1AADRA1BADRA1DOPRM1 | |
| SCHEMBL7748912 | 0.78 | ADRA1A (0.67) | ADRA1AADRA1BADRA1DOPRM1 | |
| SCHEMBL7218274 | 0.76 | ADRA1A (0.57) | ADRA1AADRA1BADRA1DHRH1 | |
| SCHEMBL6961423 | 0.75 | DRD2 (0.43) | ADRA1AADRA1BADRA1DOPRM1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620815-B1 | Selective antagonists for human alpha 1A receptors; benign prostatic hyperplasia, impotency, cardiac arrhythmia treatment; anticholesterol agents; intraocular pressure reduction | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-09-16 | — | — | US | disclosed |
| US-6159990-A | Oxazolidinones as α1A receptor antagonists | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |