Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 5/20 | 0.38 |
| ▸ | THRB | P10828 | 5/20 | 0.38 |
| ▸ | RXRA | P19793 | 7/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HNF4A | P41235 | 1/20 | 0.34 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212192 | 0.82 | RXRA (0.33) | THRATHRBRXRAPPARGNR1H3 | |
| SCHEMBL6874366 | 0.81 | RXRA (0.49) | THRATHRBRXRAPPARGNR1H3 | |
| SCHEMBL7212269 | 0.80 | PDK2 (0.46) | THRATHRBGAA | |
| SCHEMBL6479338 | 0.79 | RXRA (0.47) | THRATHRBRXRAPPARGNR1H3 | |
| SCHEMBL7212117 | 0.76 | RXRA (0.33) | RXRAPPARGNR1H3PTPN1 | |
| SCHEMBL2053781 | 0.73 | THRA (0.49) | THRATHRBS1PR3S1PR2S1PR1 | |
| SCHEMBL2049161 | 0.73 | THRA (0.49) | THRATHRBS1PR3S1PR2S1PR1 | |
| SCHEMBL339836 | 0.73 | THRA (0.49) | THRATHRBS1PR3S1PR2S1PR1 | |
| SCHEMBL197292 | 0.73 | THRA (0.49) | THRATHRBS1PR3S1PR2S1PR1 | |
| SCHEMBL339687 | 0.73 | THRA (0.49) | THRATHRBS1PR3S1PR2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610877-B1 | Treating photo and/or age damaged skin | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | disclosed |
| US-5700836-A | TOPICALLY ADMINISTERING TO TREAT PHOTODAMAGED SKIN | HOFFMANN-LA ROCHE INC. (US) | 1997-12-23 | — | — | US | disclosed |
| EP-0641759-A1 | Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | disclosed |