Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212117 | 0.96 | RXRA (0.33) | RXRAPPARGNR1H3PTPN1 | |
| SCHEMBL7212372 | 0.85 | RXRA (0.34) | RXRAPPARGNR1H3CNR1CNR2 | |
| SCHEMBL8905399 | 0.85 | RXRA (0.34) | RXRAPPARGNR1H3CNR1CNR2 | |
| SCHEMBL7212199 | 0.82 | THRA (0.38) | RXRAPPARGNR1H3THRATHRB | |
| SCHEMBL8904568 | 0.74 | RXRA (0.35) | RXRACNR1CNR2 | |
| SCHEMBL8522363 | 0.74 | RXRA (0.37) | RXRAPPARGNR1H3 | |
| SCHEMBL6874366 | 0.74 | RXRA (0.49) | RXRAPPARGNR1H3THRATHRB | |
| SCHEMBL6479338 | 0.72 | RXRA (0.47) | RXRAPPARGNR1H3THRATHRB | |
| SCHEMBL2053781 | 0.67 | THRA (0.49) | THRATHRB | |
| SCHEMBL197292 | 0.67 | THRA (0.49) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610877-B1 | Treating photo and/or age damaged skin | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | disclosed |
| EP-0641759-A1 | Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | disclosed |