Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 9/20 | 0.41 |
| ▸ | THRB | P10828 | 8/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218367 | 0.87 | LSS (0.46) | — | |
| SCHEMBL7213385 | 0.78 | THRA (0.40) | THRATHRBMAOAMAOBHTR2A | |
| SCHEMBL7218490 | 0.71 | LSS (0.40) | — | |
| SCHEMBL7212197 | 0.69 | LSS (0.36) | — | |
| SCHEMBL7212194 | 0.69 | LSS (0.52) | — | |
| SCHEMBL7212195 | 0.69 | LTA4H (0.34) | MAOAMAOBPDE3BPDE3A | |
| SCHEMBL7162166 | 0.69 | THRA (0.47) | THRATHRBLMNA | |
| SCHEMBL7166192 | 0.68 | THRA (0.49) | THRATHRBMAOBLMNA | |
| SCHEMBL7212241 | 0.67 | HRH3 (0.48) | THRATHRBMAOBLMNA | |
| SCHEMBL7162165 | 0.66 | LTA4H (0.49) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358162-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002050041-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-27 | — | — | WO | disclosed |