Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994715 | 0.84 | KMT2A (0.49) | KMT2ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL7615988 | 0.82 | KMT2A (0.50) | KMT2ASMN1; SMN2NPC1ALDH1A1POLB | |
| SCHEMBL2211499 | 0.82 | ALDH1A1 (0.41) | KMT2AALDH1A1POLBMEN1HTT | |
| SCHEMBL4445330 | 0.82 | KMT2A (0.50) | KMT2ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL5715738 | 0.79 | KMT2A (0.51) | KMT2AALDH1A1POLBMEN1HTT | |
| SCHEMBL9226868 | 0.77 | MAPT (0.63) | KMT2ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL14259711 | 0.77 | KMT2A (0.60) | KMT2ASMN1; SMN2ALDH1A1POLBMEN1 | |
| SCHEMBL14754995 | 0.77 | KMT2A (0.62) | KMT2AALDH1A1POLBMEN1HTT | |
| SCHEMBL6130227 | 0.75 | KMT2A (0.47) | KMT2ASMN1; SMN2NPC1ALDH1A1POLB | |
| SCHEMBL5572022 | 0.74 | KMT2A (0.50) | KMT2ASMN1; SMN2RAB9AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288280-B1 | HEATING COMPOUND FOR RACEMIZATION ATROPISOMERIC BIS(PHOSPHINE OXIDE) COMPOUNDS | HOFFMANN-LA ROCHE INC. | 2001-09-11 | — | — | US | claimed |
| EP-1067133-B1 | Process for the racemization of atropisomeric bis (phosphine oxide) compounds | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| EP-0926152-B1 | Process for the manufacture of bis(phosphine oxide)-and bis(phosphonate)-compounds | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| EP-1067133-A1 | Process for the racemization of atropisomeric bis (phosphine oxide) compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-10 | — | — | EP | disclosed |
| US-6162929-A | Process for the manufacture of bisphosphine oxide and bisphosphonate compounds | HOFFMANN-LA ROCHE INC. (US) | 2000-12-19 | — | — | US | disclosed |
| EP-0926152-A1 | Process for the manufacture of bis(phosphine oxide)-and bis(phosphonate)-compounds | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-30 | — | — | EP | disclosed |
| US-5488172-A | Chiral phosphorus compounds | HOFFMANN-LA ROCHE INC. (US) | 1996-01-30 | — | — | US | disclosed |