Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707969 | 0.84 | ALDH1A1 (0.39) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL7212732 | 0.82 | KMT2A (0.51) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL2210519 | 0.80 | POLB (0.43) | ALDH1A1KDM4EKMT2AMEN1HTT | |
| SCHEMBL2208362 | 0.79 | KMT2A (0.39) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL2208355 | 0.79 | KMT2A (0.39) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL7712031 | 0.78 | NPSR1 (0.38) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL7713840 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL4445330 | 0.77 | KMT2A (0.50) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL4846499 | 0.77 | MEN1 (0.42) | ALDH1A1KMT2AMEN1HTTPOLB | |
| SCHEMBL4842166 | 0.77 | CXCR5 (0.41) | ALDH1A1KMT2AMEN1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981827-B2 | Chiral phosphanes for use in asymmetric syntheses | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-19 | — | — | US | disclosed |
| US-20100099902-A1 | CHIRAL PHOSPHANES FOR USE IN ASYMMETRIC SYNTHESES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-22 | — | — | US | disclosed |
| US-7625443-B2 | Chiral phosphanes for use in asymmetric syntheses | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7396947-B2 | Chiral ligands for application in asymmetric syntheses | LANXESS DEUTSCHLAND GMBH (DE) | 2008-07-08 | — | — | US | disclosed |
| US-20070004927-A1 | Chiral ligands for application in asymmetric syntheses | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-04 | — | — | US | disclosed |
| US-20060161022-A1 | Chiral ligands for application in asymmetric syntheses | LANXESS DEUTSCHLAND GMBH (DE) | 2006-07-20 | — | — | US | disclosed |
| US-20050085377-A1 | Chiral phosphanes for use in asymmetric syntheses | LIGAND CHEMIE GMBH (DE) | 2005-04-21 | — | — | US | disclosed |
| EP-1205486-B1 | Improved method for the preparation of enantiomerically pure (5,5'-dichloro-6,6'-dimethoxybiphenyl-2,2'-diyl)-bis-(diphenylphosphine oxides) | BAYER CHEMICALS AG (DE) | 2004-02-11 | — | — | EP | disclosed |
| US-6489513-B2 | REACTING AROMATIC BROMINE COMPOUND WITH DIPHENYLPHOSPHINIC CHLORIDE IN A MIXTURE OF TETRAHYDROFURAN AND AROMATIC HYDROCARBON TO GIVE A DIPHENYLPHOSPHINE OXIDE, ISOLATING, METALATING; REACTING WITH IODINE, REACTING WITH COPPER | BAYER AKTIENGESELLSCHAFT (DE) | 2002-12-03 | — | — | US | disclosed |
| US-6489513-B2 | REACTING AROMATIC BROMINE COMPOUND WITH DIPHENYLPHOSPHINIC CHLORIDE IN A MIXTURE OF TETRAHYDROFURAN AND AROMATIC HYDROCARBON TO GIVE A DIPHENYLPHOSPHINE OXIDE, ISOLATING, METALATING; REACTING WITH IODINE, REACTING WITH COPPER | BAYER AKTIENGESELLSCHAFT (DE) | 2002-12-03 | — | — | US | disclosed |
| US-20020058814-A1 | Process for the preparation of enantiomerically pure (5,5'-dichloro-6,6'-dimethoxy-biphenyl-2,2'-diyl)- bis(diphenylphosphine oxides) | LANXESS DEUTSCHLAND GMBH (DE) | 2002-05-16 | — | — | US | disclosed |
| US-20020058814-A1 | Process for the preparation of enantiomerically pure (5,5'-dichloro-6,6'-dimethoxy-biphenyl-2,2'-diyl)- bis(diphenylphosphine oxides) | LANXESS DEUTSCHLAND GMBH (DE) | 2002-05-16 | — | — | US | disclosed |
| EP-1205486-A1 | Improved method for the preparation of enantiomerically pure (5,5'-dichloro-6,6'-dimethoxybiphenyl-2,2'-diyl)-bis-(diphenylphosphine oxides) | Bayer Aktiengesellschaft (DE) | 2002-05-15 | — | — | EP | disclosed |
| US-5801261-A | Bisphosphines as catalysts for asymmetric reactions | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-01 | — | — | US | disclosed |
| US-5710339-A | REACTION OF PHOSPHOROUS OXYCHLORIDE WITH 5-BROMO-2-CHLORO ANISOLE AND REACTION WITH GRIGNARD REAGENT, LITHIUM AMIDE AND IODINE FOR DIMERIZATION THEN COMPLEXING | BAYER AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099902-A1 | CHIRAL PHOSPHANES FOR USE IN ASYMMETRIC SYNTHESES | PHOSPHO1, AGPS, GGPS1 | ALDH1A1 2609/4885KDM4E 3985/4885HSD17B10 610/4885 |
| US-20050085377-A1 | Chiral phosphanes for use in asymmetric syntheses | PHOSPHO1, AGPS, GGPS1 | ALDH1A1 2609/4885KDM4E 3985/4885HSD17B10 610/4885 |
| US-20070004927-A1 | Chiral ligands for application in asymmetric syntheses | COASY, SPR, DHPS | ALDH1A1 348/4885KDM4E 4280/4885HSD17B10 178/4885 |
| US-20060161022-A1 | Chiral ligands for application in asymmetric syntheses | COASY, SPR, DHPS | ALDH1A1 348/4885KDM4E 4280/4885HSD17B10 178/4885 |
| US-20020058814-A1 | Process for the preparation of enantiomerically pure (5,5'-dichloro-6,6'-dimethoxy-biphenyl-2,2'-diyl)- bis(diphenylphosphine oxides) | DDT, HDHD5, DDC | ALDH1A1 1625/4885KDM4E 2145/4885HSD17B10 1761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.