Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8701445 | 0.84 | HSD17B10 (0.56) | HTTMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL7212819 | 0.78 | TTR (0.53) | L3MBTL1TTRHPGDHTTTSHR | |
| SCHEMBL597834 | 0.78 | L3MBTL1 (0.69) | L3MBTL1TTRHTTTSHRMEN1 | |
| SCHEMBL29270111 | 0.76 | KMT2A (0.61) | L3MBTL1TTRHPGDHTTTSHR | |
| SCHEMBL31040323 | 0.74 | L3MBTL1 (0.72) | L3MBTL1TTRHPGDHTTTSHR | |
| SCHEMBL5725941 | 0.74 | L3MBTL1 (0.68) | L3MBTL1TTRHTTTSHRMEN1 | |
| SCHEMBL9057785 | 0.74 | L3MBTL1 (0.72) | L3MBTL1TTRHPGDHTTTSHR | |
| SCHEMBL800460 | 0.73 | HPGD (0.54) | TTRHPGDHTTTSHRMEN1 | |
| SCHEMBL24603113 | 0.71 | L3MBTL1 (0.65) | L3MBTL1TTRHTTTSHRMEN1 | |
| SCHEMBL332837 | 0.71 | TTR (0.66) | L3MBTL1TTRHPGDHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-B1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER LAMBERT CO (US) | 2003-02-05 | — | — | EP | claimed |
| US-5633287-A | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents | WARNER-LAMBERT COMPANY (US) | 1997-05-27 | — | — | US | disclosed |