Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207810 | 0.79 | SMN1; SMN2 (0.41) | TTRATMHPGDHTTMAPT | |
| SCHEMBL7206388 | 0.79 | TSHR (0.41) | HIF1AL3MBTL1CNR2HPGDHTT | |
| SCHEMBL7212823 | 0.78 | L3MBTL1 (0.50) | TTRL3MBTL1HPGDHTTMEN1 | |
| SCHEMBL7206345 | 0.75 | GABRA1 (0.41) | HIF1AHPGDMEN1TSHRKMT2A | |
| SCHEMBL332837 | 0.75 | TTR (0.66) | TTRHIF1AL3MBTL1CNR2ATM | |
| SCHEMBL236891 | 0.72 | TTR (0.70) | TTRHIF1AL3MBTL1CNR2ATM | |
| SCHEMBL758911 | 0.71 | TTR (0.61) | TTRHIF1AL3MBTL1CNR2ATM | |
| SCHEMBL1246697 | 0.70 | RAB9A (0.65) | TTRHIF1AL3MBTL1HPGDHTT | |
| SCHEMBL800460 | 0.70 | HPGD (0.54) | TTRATMHPGDHTTMAPT | |
| SCHEMBL710329 | 0.70 | LMNA (0.56) | TTRL3MBTL1ATMMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-B1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER LAMBERT CO (US) | 2003-02-05 | — | — | EP | claimed |
| US-5633287-A | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents | WARNER-LAMBERT COMPANY (US) | 1997-05-27 | — | — | US | disclosed |