SCHEMBL7213034

SCHEMBL7213034

O=C(Nc1cccc(C(F)(F)F)c1)c1cc(Br)ccc1NS(=O)(=O)c1ccc(Cl)s1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
MAPT P10636 4/20 0.57
LMNA P02545 3/20 0.57
SMN1; SMN2 Q16637 3/20 0.57
HTT P42858 3/20 0.51
RECQL P46063 2/20 0.51
ALDH1A1 P00352 1/20 0.50
POLB P06746 1/20 0.50
OPRK1 P41145 1/20 0.50
RXFP1 Q9HBX9 9/20 0.49
SLC10A2 Q12908 1/20 0.49
SLC10A1 Q14973 1/20 0.49
SLC10A6 Q3KNW5 1/20 0.49
MPO P05164 1/20 0.48
SLC20A2 Q08357 1/20 0.48
SLC20A1 Q8WUM9 1/20 0.48
TP53 P04637 1/20 0.48
GRIK1 P39086 1/20 0.46
TMPRSS4 Q9NRS4 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7213170 0.86 MEN1 (0.76) MEN1KMT2AMAPTLMNASMN1; SMN2
SCHEMBL7120571 0.84 SMN1; SMN2 (0.65) MEN1KMT2AMAPTLMNASMN1; SMN2
SCHEMBL5117189 0.84 SLC10A6 (0.72) MEN1KMT2AMAPTLMNAHTT
SCHEMBL7213029 0.83 SLC20A2 (0.60) MEN1KMT2AHTTOPRK1RXFP1
SCHEMBL7214479 0.82 SLC10A6 (0.72) MEN1KMT2AMAPTLMNASMN1; SMN2
SCHEMBL27179917 0.81 MEN1 (0.63) MEN1KMT2AMAPTLMNASMN1; SMN2
SCHEMBL7209341 0.79 SLC20A2 (0.62) MEN1KMT2AMAPTHTTALDH1A1
SCHEMBL7128725 0.77 SLC20A2 (0.66) MEN1KMT2AHTTOPRK1RXFP1
SCHEMBL21384611 0.77 MEN1 (0.50) MEN1KMT2AMAPTLMNASMN1; SMN2
SCHEMBL5115424 0.75 SLC20A2 (0.66) MEN1KMT2AMAPTLMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1187531-A4 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-28 EP claimed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US claimed
EP-1187531-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2002-03-20 EP claimed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO claimed
WO-2000078145-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-12-28 WO claimed
EP-1187531-A4 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-28 EP disclosed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US disclosed
EP-1187531-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2002-03-20 EP disclosed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO disclosed
WO-2000078145-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-12-28 WO disclosed