Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030499 | 0.80 | GRM8 (0.54) | GRM8GRM4TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3497625 | 0.80 | TDP1 (0.49) | GRM8GRM4TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5898971 | 0.76 | GRM8 (0.46) | GRM8GRM4TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL27744454 | 0.75 | MEN1 (0.49) | TDP1ALDH1A1SMN1; SMN2MAPK1GPR35 | |
| SCHEMBL10594916 | 0.75 | TDP1 (0.46) | GRM8GRM4TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10616262 | 0.75 | MEN1 (0.49) | TDP1ALDH1A1SMN1; SMN2MAPK1GPR35 | |
| SCHEMBL9398085 | 0.75 | TDP1 (0.56) | GRM8GRM4TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5497079 | 0.75 | TDP1 (0.56) | GRM8GRM4TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2129944 | 0.73 | ALDH1A1 (0.49) | TDP1ALDH1A1SMN1; SMN2MAPK1GPR35 | |
| SCHEMBL10662852 | 0.72 | GRM8 (0.52) | GRM8GRM4TDP1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939628-B1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 2003-03-05 | — | — | EP | disclosed |