Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030499 | 0.83 | GRM8 (0.54) | GRM8GRM4MAPTMEN1KMT2A | |
| SCHEMBL3497625 | 0.78 | TDP1 (0.49) | GRM8GRM4MAPTLMNAKMT2A | |
| SCHEMBL26934198 | 0.77 | ALDH1A1 (0.58) | MAPTALDH1A1CRHBPCRHR2TDP1 | |
| SCHEMBL26934190 | 0.77 | ALDH1A1 (0.58) | MAPTALDH1A1CRHBPCRHR2TDP1 | |
| SCHEMBL21981237 | 0.76 | ALDH1A1 (0.49) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL10662852 | 0.76 | GRM8 (0.52) | GRM8GRM4MAPTLMNAMEN1 | |
| SCHEMBL7213380 | 0.76 | GRM8 (0.42) | GRM8GRM4MAPTLMNAKMT2A | |
| SCHEMBL2130850 | 0.75 | ALDH1A1 (0.50) | GRM8GRM4MAPTLMNAMEN1 | |
| SCHEMBL29478417 | 0.75 | GRM8 (0.56) | GRM8GRM4MAPTMEN1KMT2A | |
| SCHEMBL3584980 | 0.75 | ALDH1A1 (0.50) | GRM8GRM4MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115632-B1 | Sulfonyl aryl or heteroaryl hydroxamic acid compounds | G. D. SEARLE & CO. (US) | 2006-10-03 | — | — | US | disclosed |
| US-7067670-B2 | Sulfamato hydroxamic acid metalloprotease inhibitor | WARNER LAMBERT COMPANY (US) | 2006-06-27 | — | — | US | disclosed |
| US-20060084688-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | BARTA THOMAS E | 2006-04-20 | — | — | US | disclosed |
| US-6890937-B2 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION (US) | 2005-05-10 | — | — | US | disclosed |
| US-20050075374-A1 | Sulfonyl aryl or heteroaryl hydroxamic acid compounds | PHARMACIA CORPORATION | 2005-04-07 | — | — | US | disclosed |
| US-20050049280-A1 | Sulfamato hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2005-03-03 | — | — | US | disclosed |
| EP-0983267-B1 | AMIDOAROMATIC RING SULFONAMIDE HYDROXAMIC ACID COMPOUNDS | PHARMACIA CORP (US) | 2005-01-26 | — | — | EP | disclosed |
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | PHARMACIA CORPORATION | 2005-01-20 | — | — | US | disclosed |
| EP-0977745-B1 | THIOARYL SULFONAMIDE HYDROXAMIC ACID COMPOUNDS | PHARMACIA CORP (US) | 2004-12-01 | — | — | EP | disclosed |
| US-20040235818-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2004-11-25 | — | — | US | disclosed |
| WO-2002062756-A1 | AROMATIC SULFONYL ALPHA-CYCLOAMINO HYDROXAMATES AND THEIR USE AS MMP INHIBITORS | PHARMACIA CORPORATION (US) | 2002-08-15 | — | — | WO | disclosed |
| US-20020103239-A1 | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds | BEDELL LOUIS J (US) | 2002-08-01 | — | — | US | disclosed |
| US-6380258-B2 | METALLOPROTEASE INHIBITOR | G. D. SEARLE, L.L.C. | 2002-04-30 | — | — | US | disclosed |
| US-6362183-B1 | PROTEASE INHIBITORS; RHEUMATIC DISEASES; ANTITUMOR AGENTS | G. D. SEARLE & COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-20010049449-A1 | Aromatic sulfonyl alpha-cycloamino hydroxamates and their use as MMP inhibitors | PHARMACIA CORPORATION | 2001-12-06 | — | — | US | disclosed |
| US-20010039287-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | PHARMACIA CORPORATION | 2001-11-08 | — | — | US | disclosed |
| US-20010020021-A1 | SULFONYL DIVALENT ARYL OR HETEROARYL HYDROXAMIC ACID COMPOUNDS | G.D. SEARLE & CO. | 2001-09-06 | — | — | US | disclosed |
| US-20010014688-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | BARTA THOMAS E (US) | 2001-08-16 | — | — | US | disclosed |
| US-6087359-A | A MATRIX METALLOPROTEASE ENZYME INHIBITOR | PHARMACIA CORPORATION | 2000-07-11 | — | — | US | disclosed |
| US-6013649-A | BOND DISORDERS; AUTOIMMUNE DISEASES; ANTITUMOR AGENTS | MONSANTO COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020021-A1 | SULFONYL DIVALENT ARYL OR HETEROARYL HYDROXAMIC ACID COMPOUNDS | MMP2, MMP1, MMP3 | GRM8 3870/4885GRM4 3294/4885MAPT 4679/4885 |
| US-20010049449-A1 | Aromatic sulfonyl alpha-cycloamino hydroxamates and their use as MMP inhibitors | MMP1, MMP3, MMP2 | GRM8 3898/4885GRM4 3528/4885MAPT 3787/4885 |
| US-20050075374-A1 | Sulfonyl aryl or heteroaryl hydroxamic acid compounds | MMP1, MMP2, MMP3 | GRM8 4380/4885GRM4 3994/4885MAPT 4693/4885 |
| US-20020103239-A1 | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds | MMP2, MMP1, MMP3 | GRM8 3870/4885GRM4 3294/4885MAPT 4679/4885 |
| US-20040235818-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | MMP9, MMP13, MMP2 | GRM8 4761/4885GRM4 4722/4885MAPT 2855/4885 |
| US-20060084688-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | MMP13, MMP9, MMP3 | GRM8 4551/4885GRM4 4618/4885MAPT 3840/4885 |
| US-20010039287-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | MMP13, MMP9, MMP10 | GRM8 4561/4885GRM4 4592/4885MAPT 2312/4885 |
| US-20050049280-A1 | Sulfamato hydroxamic acid metalloprotease inhibitor | MMP14, MMP12, MMP17 | GRM8 2840/4885GRM4 2611/4885MAPT 3934/4885 |
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | MMP12, MMP13, MMP3 | GRM8 3725/4885GRM4 4368/4885MAPT 1644/4885 |
| US-20010014688-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | MMP13, MMP9, MMP10 | GRM8 4561/4885GRM4 4592/4885MAPT 2312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.