Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.64 |
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | FLT1 | P17948 | 5/20 | 0.55 |
| ▸ | FLT4 | P35916 | 5/20 | 0.55 |
| ▸ | KDR | P35968 | 5/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209934 | 0.85 | FLT1 (0.79) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL6276451 | 0.84 | FLT1 (0.67) | PTGS2PTGS1FLT1FLT4KDR | |
| SCHEMBL7319458 | 0.84 | FLT1 (0.58) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL14282630 | 0.81 | FLT1 (0.51) | PTGS2FLT1FLT4KDRMEN1 | |
| SCHEMBL24347999 | 0.81 | PTGS2 (0.67) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL4464235 | 0.81 | PTGS2 (0.71) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL7213397 | 0.79 | PTGS2 (0.64) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL7367486 | 0.78 | PTGS2 (0.68) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL8203822 | 0.78 | FLT1 (0.77) | PTGS2PTGS1EGFRFLT1FLT4 | |
| SCHEMBL27901399 | 0.76 | MEN1 (0.57) | PTGS2PTGS1EGFRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172044-B1 | ELASTASE INHIBITORS; ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS | AVENTIS PHARMACEUTICALS INC. | 2001-01-09 | — | — | US | claimed |
| EP-0863915-B1 | ACYLATED ENOL DERIVATIVES OF ALPHA-KETOESTERS AND ALPHA-KETOAMIDES | HOECHST MARION ROUSSEL INC (US) | 2000-02-02 | — | — | EP | claimed |
| US-5948886-A | ELASTASE INHIBITORS OR PRODRUGS; FOR TREATMENT OF EMPHYSEMA, CYSTIC FIBROSIS, ADULT RESPIRATORY DISTRESS SYNDROME, GOUT, DISSEMINATED INTRAVASCULAR COAGULATION, RHEUMATOID ARTHRITIS, CHRONIC BRONCHITIS, INFLAMMATORY BOWEL DISEASE, SEPTICEMIA | HOECHST MARION ROUSSEL, INC. (US) | 1999-09-07 | — | — | US | claimed |
| EP-0362002-B1 | HIV protease inhibitors | MERRELL DOW PHARMA (US) | 1995-07-26 | — | — | EP | claimed |
| US-6617426-B1 | Peptide analogs of given formula; useful in treating neurodegenerative, autoimmune, cognitive disorders, stroke and traumatic injury | MERCK SHARP & DOHME CORP. | 2003-09-09 | — | — | US | disclosed |
| US-6172044-B1 | ELASTASE INHIBITORS; ANTIINFLAMMATORY AGENTS; RESPIRATORY SYSTEM DISORDERS | AVENTIS PHARMACEUTICALS INC. | 2001-01-09 | — | — | US | disclosed |
| EP-0707564-B1 | DIFLUORO STATONE ANALOGS | MERRELL PHARMA INC (US) | 2000-09-20 | — | — | EP | disclosed |
| US-6114380-A | ANTIVIRAL AGENT; ADMINISTERING TO TREAT HIV INFECTION; N-(4-(N-BENZYLOXYCARBONYL-L-VALYL)AMINO-2,2-DIFLUORO-1,3-DIOXO-5-(4-(2-N -MORPHOLYL)ETHYLOXY)PHENYL-PENTYL)-O-((2-PYRIDYL)METHYL)-D-VALINOL, FOR EXAMPLE | MERRELL PHARMACEUTICALS INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0863915-B1 | ACYLATED ENOL DERIVATIVES OF ALPHA-KETOESTERS AND ALPHA-KETOAMIDES | HOECHST MARION ROUSSEL INC (US) | 2000-02-02 | — | — | EP | disclosed |
| US-5948886-A | ELASTASE INHIBITORS OR PRODRUGS; FOR TREATMENT OF EMPHYSEMA, CYSTIC FIBROSIS, ADULT RESPIRATORY DISTRESS SYNDROME, GOUT, DISSEMINATED INTRAVASCULAR COAGULATION, RHEUMATOID ARTHRITIS, CHRONIC BRONCHITIS, INFLAMMATORY BOWEL DISEASE, SEPTICEMIA | HOECHST MARION ROUSSEL, INC. (US) | 1999-09-07 | — | — | US | disclosed |
| EP-0717731-B1 | DIFLUORO STATONE ANTIVIRAL ANALOGS | MERRELL PHARMA INC (US) | 1999-04-21 | — | — | EP | disclosed |
| EP-0364344-B1 | Novel peptidase inhibitors | MERRELL PHARMA INC (US) | 1998-05-06 | — | — | EP | disclosed |
| WO-1992012123-A1 | ANTI-VIRAL COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-23 | — | — | WO | disclosed |
| US-5114927-A | Hypotensive agents and inhibiting renin | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0417721-A2 | Novel peptidase and isomerase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-03-20 | — | — | EP | disclosed |
| EP-0410411-A2 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-01-30 | — | — | EP | disclosed |
| EP-0371179-A1 | Novel analogs of peptidase substrates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0368719-A2 | Novel analogs of peptidase substrates | MERRELL PHARMACEUTICALS INC. (US) | 1990-05-16 | — | — | EP | disclosed |
| EP-0364344-A2 | Novel peptidase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1990-04-18 | — | — | EP | disclosed |
| EP-0356595-A1 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-07 | — | — | EP | disclosed |