Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ECE1 | P42892 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208522 | 0.89 | NPC1 (0.44) | CTSLCTSBCTSSMMEECE1 | |
| SCHEMBL7212923 | 0.89 | NPC1 (0.44) | CTSLCTSBCTSSMMEECE1 | |
| SCHEMBL4265208 | 0.84 | NPC1 (0.47) | RAB9ANPC1HSD17B10 | |
| SCHEMBL7214212 | 0.84 | NPC1 (0.47) | RAB9ANPC1HSD17B10 | |
| SCHEMBL7445411 | 0.80 | CTSB (0.48) | CTSLCTSBCTSSMMEECE1 | |
| SCHEMBL7207876 | 0.80 | NPC1 (0.43) | CTSLCTSSRAB9ACTSKNPC1 | |
| SCHEMBL7212869 | 0.80 | CTSK (0.46) | CTSLCTSBCTSSRAB9ACTSK | |
| SCHEMBL7212770 | 0.80 | CTSK (0.46) | CTSLCTSBCTSSRAB9ACTSK | |
| SCHEMBL10004508 | 0.79 | RAB9A (0.46) | CTSLCTSBCTSSMMEECE1 | |
| SCHEMBL30547455 | 0.79 | ELANE (0.44) | CTSLCTSBCTSSMMEECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150988-B1 | PHOSPHORAMIDATE, AND MONO-, DI-, AND TRI-PHOSPHATE ESTERS OF (1R, CIS)-4-(6-AMINO-9H-PURIN-9-YL)-2-CYCLOPENTENE-1-METHANOL AS ANTIVIRAL AGENTS | GLAXO GROUP LTD (GB) | 2003-05-28 | — | — | EP | claimed |