Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 11/20 | 0.51 |
| ▸ | CA2 | P00918 | 11/20 | 0.51 |
| ▸ | CA9 | Q16790 | 8/20 | 0.51 |
| ▸ | CA12 | O43570 | 5/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250413 | 0.78 | TSHR (0.44) | ALDH1A1KDM4ELMNA | |
| SCHEMBL8502556 | 0.76 | PTGES2 (0.42) | CA1CA2CA9CA12ALDH1A1 | |
| SCHEMBL14341830 | 0.71 | LMNA (0.59) | CA1CA2CA9CA12PTGS1 | |
| SCHEMBL3424339 | 0.70 | PTGS2 (0.59) | CA1CA2CA9CA12PTGS1 | |
| SCHEMBL9494422 | 0.70 | LMNA (0.57) | CA1CA2CA9CA12PTGS1 | |
| SCHEMBL6841898 | 0.69 | CHRNA7 (0.59) | CA1CA2CA9CA12PTGS1 | |
| SCHEMBL8144039 | 0.69 | ATM (0.42) | ALDH1A1KDM4ELMNA | |
| SCHEMBL6013987 | 0.69 | PTGS2 (0.60) | CA1CA2CA9CA12PTGS1 | |
| SCHEMBL6013942 | 0.69 | PTGS2 (0.60) | CA1CA2CA9CA12PTGS1 | |
| SCHEMBL10059528 | 0.68 | CA12 (0.54) | CA1CA2CA9CA12PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1369415-A1 | Substituted pyrrolyl compounds for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2003-12-10 | — | — | EP | claimed |
| EP-0946507-B1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2003-09-24 | — | — | EP | claimed |
| EP-1369415-A1 | Substituted pyrrolyl compounds for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2003-12-10 | — | — | EP | disclosed |