Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 5/20 | 0.51 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSH | P09668 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358274 | 0.90 | CASP3 (0.52) | CASP3CTSKCTSBCTSHCTSS | |
| SCHEMBL7358261 | 0.90 | CASP3 (0.52) | CASP3CTSKCTSBCTSHCTSS | |
| SCHEMBL7358268 | 0.90 | CASP3 (0.52) | CASP3CTSKCTSBCTSHCTSS | |
| SCHEMBL19015816 | 0.84 | CASP3 (0.51) | CASP3CTSKCTSBCTSHCTSS | |
| SCHEMBL8127874 | 0.83 | CTSB (0.62) | CTSKCTSBCTSHCTSSCTSC | |
| SCHEMBL18782008 | 0.83 | CTSK (0.47) | CASP3CTSKCTSBCTSHCTSS | |
| SCHEMBL19015814 | 0.81 | CASP3 (0.48) | CASP3CTSKCTSBCTSHCTSS | |
| SCHEMBL7352942 | 0.79 | CA1 (0.44) | CASP3CTSKCTSSCTSLMAPT | |
| SCHEMBL7352953 | 0.79 | CA1 (0.44) | CASP3CTSKCTSSCTSLMAPT | |
| SCHEMBL7352957 | 0.79 | CA1 (0.44) | CASP3CTSKCTSSCTSLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617426-B1 | Peptide analogs of given formula; useful in treating neurodegenerative, autoimmune, cognitive disorders, stroke and traumatic injury | MERCK SHARP & DOHME CORP. | 2003-09-09 | — | — | US | disclosed |