Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10383318 | 0.98 | HRH3 (0.37) | HRH3KDM4EALDH1A1SLC6A2ADRA1A | |
| SCHEMBL10349667 | 0.74 | PRCP (0.41) | KDM4EALDH1A1SLC6A2ADRA1AHTR2B | |
| Hydrochloric Acid SCHEMBL10382641 | 0.73 | PRCP (0.40) | KDM4EALDH1A1SLC6A2ADRA1AHTR2B | |
| Formamide SCHEMBL28989148 | 0.71 | HTR1A (0.42) | KDM4EALDH1A1SLC6A2ADRA1AHTR2B | |
| SCHEMBL3097614 | 0.69 | L3MBTL1 (0.38) | L3MBTL1 | |
| SCHEMBL4095157 | 0.69 | SLC6A2 (0.41) | SLC6A2HTR2BSLC6A3SLC18A3MEN1 | |
| SCHEMBL18914200 | 0.69 | SLC6A2 (0.41) | SLC6A2HTR2BSLC6A3SLC18A3MEN1 | |
| SCHEMBL18913743 | 0.69 | SLC6A2 (0.41) | SLC6A2HTR2BSLC6A3SLC18A3MEN1 | |
| SCHEMBL8222209 | 0.68 | SLC18A3 (0.52) | KDM4EALDH1A1SLC6A2ADRA1AHTR2B | |
| SCHEMBL10349649 | 0.67 | SLC6A2 (0.53) | SLC6A2ADRA1AHTR2BSLC6A3SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0211746-B1 | PHENYL-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTICAL USE | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1990-05-23 | — | — | EP | claimed |
| EP-0211746-A1 | Phenyl-piperazine derivatives, process for their preparation and therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1987-02-25 | — | — | EP | claimed |
| US-6603003-B2 | Reacting ester with substituted or unsubstituted ethylenediamine to give 3,4-dehydropiperazine-2-one and reacting 3,4-dehydropiperazine-2-one with reducing agent to yield piperazine derivative | SUN PHARMACEUTICAL INDUSTRIES LTD (IN) | 2003-08-05 | — | — | US | disclosed |
| US-20020095038-A1 | Novel method for the preparation of piperazine and its derivatives | SUN PHARMACEUTICAL INDUSTRIES LTD (IN) | 2002-07-18 | — | — | US | disclosed |
| WO-2002038552-A1 | A NOVEL METHOD FOR THE PREPARATION OF PIPERAZINE AND ITS DERIVATIVES | SUN PHARMACEUTICAL INDUSTRIES LTD. (IN) | 2002-05-16 | — | — | WO | disclosed |
| EP-0211746-B1 | PHENYL-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTICAL USE | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1990-05-23 | — | — | EP | disclosed |
| EP-0211746-B1 | PHENYL-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTICAL USE | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1990-05-23 | — | — | EP | disclosed |
| US-4912110-A | Antidepressive substituted phenylpiperazine compounds | LABORATOIRE L. LAFTON (FR) | 1990-03-27 | — | — | US | disclosed |
| EP-0211746-A1 | Phenyl-piperazine derivatives, process for their preparation and therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1987-02-25 | — | — | EP | disclosed |
| EP-0211746-A1 | Phenyl-piperazine derivatives, process for their preparation and therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1987-02-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020095038-A1 | Novel method for the preparation of piperazine and its derivatives | DHPS, DRD4, CYP2E1 | HRH3 179/4885KDM4E 525/4885ALDH1A1 116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.