Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | HTR1D | P28221 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217320 | 0.82 | ALDH1A1 (0.53) | DRD2HTR7HTR1DDRD3HTR2C | |
| SCHEMBL17277488 | 0.77 | HTR2A (0.49) | DRD2HTR7HTR1DDRD3HTR2C | |
| SCHEMBL17277400 | 0.76 | HTR2A (0.48) | DRD2HTR7HTR1DDRD3HTR2C | |
| SCHEMBL7215377 | 0.76 | KCNH2 (0.43) | DRD2HTR7HTR1DDRD3HTR2C | |
| SCHEMBL29991400 | 0.76 | KMT2A (0.62) | DRD2HTR7HTR2AHTR1ASRC | |
| SCHEMBL7221715 | 0.75 | KMT2A (0.50) | DRD2HTR7HTR1DDRD3CCR5 | |
| SCHEMBL5431476 | 0.74 | SIGMAR1 (0.59) | DRD2DRD3SIGMAR1SRC | |
| SCHEMBL29172712 | 0.74 | KMT2A (0.59) | DRD2HTR7HTR2AHTR1AHTR6 | |
| SCHEMBL29991080 | 0.74 | KMT2A (0.59) | DRD2HTR7HTR2AHTR1AHTR6 | |
| SCHEMBL14045823 | 0.74 | GAA (0.43) | HTR6CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660751-B1 | Sulfonamide derivatives as 5-HT7 receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-12-09 | — | — | US | disclosed |
| EP-1163221-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056712-A1 | SULFONAMIDE DERIVATIVES AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-09-28 | — | — | WO | disclosed |