Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215648 | 0.82 | DRD2 (0.49) | DRD2HTR7DRD3HTR1DHTR2A | |
| SCHEMBL18088399 | 0.79 | HDAC3 (0.57) | ALDH1A1HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL28092811 | 0.77 | SIGMAR1 (0.58) | ALDH1A1CXCR4HTR7HTR2AHTR2C | |
| SCHEMBL13541677 | 0.77 | CACNA1B (0.53) | ALDH1A1TSHRDRD2HTR7DRD3 | |
| SCHEMBL14025621 | 0.76 | CXCR4 (0.62) | ALDH1A1TSHRCXCR4KDM4ELMNA | |
| SCHEMBL5149238 | 0.76 | SIGMAR1 (0.72) | CXCR4HTR7HTR2AHTR2CCCR5 | |
| SCHEMBL18773879 | 0.76 | ALDH1A1 (0.57) | ALDH1A1KDM4ELMNAHTR2CPOLB | |
| SCHEMBL7215377 | 0.75 | KCNH2 (0.43) | LMNADRD2HTR7DRD3HTR1D | |
| SCHEMBL14025620 | 0.74 | CXCR4 (0.57) | ALDH1A1TSHRCXCR4KDM4ELMNA | |
| SCHEMBL4920954 | 0.73 | CXCR4 (0.77) | ALDH1A1TSHRCXCR4KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660751-B1 | Sulfonamide derivatives as 5-HT7 receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-12-09 | — | — | US | disclosed |