SCHEMBL7215823

SCHEMBL7215823

CCC(C#N)(Cc1ccccc1)NC(C)=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.50
RECQL P46063 2/20 0.50
MMP8 P22894 2/20 0.44
CYP3A4 P08684 2/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
CTSS P25774 2/20 0.43
CTSK P43235 2/20 0.43
CTSL P07711 1/20 0.40
RIPK1 Q13546 1/20 0.39
ACACB O00763 1/20 0.39
CYP1A2 P05177 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HIF1A Q16665 1/20 0.38
MAPT P10636 1/20 0.38
MAPK1 P28482 1/20 0.38
THRB P10828 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37
MCL1 Q07820 1/20 0.36
MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7219578 0.85 L3MBTL1 (0.44) ALDH1A1RECQLCYP3A4CYP2C9CYP2C19
SCHEMBL7220797 0.83 ACACB (0.46) ACACBSMN1; SMN2MAPTKMT2A
SCHEMBL27804159 0.79 LMNA (0.48) ALDH1A1CYP3A4CYP2C9CYP2C19RIPK1
SCHEMBL17596548 0.78 ALDH1A1 (0.42) ALDH1A1RECQLMMP8CYP3A4CYP2C9
SCHEMBL22458401 0.72 ALDH1A1 (0.52) ALDH1A1RECQLMMP8CYP3A4CYP2C9
SCHEMBL7220861 0.72 ALDH1A1 (0.39) ALDH1A1RECQLCYP3A4CYP2C19CTSS
SCHEMBL6514301 0.72 ALDH1A1 (0.65) ALDH1A1RECQLMMP8CYP3A4CYP2C9
SCHEMBL28168069 0.70 ALDH1A1 (0.67) ALDH1A1RECQLMMP8CYP3A4CYP2C9
SCHEMBL25846939 0.70 ALDH1A1 (0.54) ALDH1A1RECQLMMP8CYP3A4CYP2C9
SCHEMBL3830647 0.70 CYP3A4 (0.50) ALDH1A1RECQLMMP8CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6504046-B1 Cyclization of nitriles using acids, to form oxazolinone chemical intermediates such as 2-phenyl-4-isopropyl-4-methyl-1,3-oxazol-5-one, used as fungicides IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2003-01-07 US disclosed
EP-1092705-A1 PROCESS FOR THE PREPARATION OF AMIDES IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) 2001-04-18 EP disclosed