Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8853249 | 0.83 | TDP1 (0.62) | TDP1LMNAALDH1A1GAATP53 | |
| SCHEMBL28569602 | 0.82 | TDP1 (0.59) | TDP1LMNAALDH1A1GAATP53 | |
| SCHEMBL9076943 | 0.79 | TDP1 (0.56) | TDP1LMNAALDH1A1GAATP53 | |
| SCHEMBL11167658 | 0.77 | TDP1 (0.50) | TDP1LMNAALDH1A1GAATP53 | |
| SCHEMBL28908606 | 0.76 | TNF (0.60) | TDP1LMNAALDH1A1POLBMAPK1 | |
| SCHEMBL1757227 | 0.76 | TDP1 (0.53) | TDP1LMNAALDH1A1GAAPOLB | |
| SCHEMBL9502955 | 0.76 | LMNA (0.63) | TDP1LMNAALDH1A1GAATP53 | |
| SCHEMBL4414650 | 0.75 | TDP1 (0.51) | TDP1LMNAALDH1A1TP53POLB | |
| SCHEMBL5194206 | 0.74 | TDP1 (0.62) | TDP1LMNAALDH1A1GAATP53 | |
| SCHEMBL4106122 | 0.74 | TDP1 (0.62) | TDP1LMNAALDH1A1GAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566384-B1 | For therapy of cancer, inflammation and inflammatory diseases, tissue degeneration, periodontal disease, ophthalmological disease, dermatological disorders, fever, cardiovascular effects, haemorrhage, coagulation and acute phase response | DARWIN DISCOVERY LTD. (GB) | 2003-05-20 | — | — | US | disclosed |