Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.57 |
| ▸ | TOP2A | P11388 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16072070 | 0.95 | TOP2A (0.64) | TERTTOP2AKDM4EMAOASMN1; SMN2 | |
| Meridine SCHEMBL2926298 | 0.89 | TERT (0.60) | TERTTOP2AKDM4EMAOASMN1; SMN2 | |
| SCHEMBL22144889 | 0.77 | TOP2A (0.66) | TERTTOP2AMAOASMN1; SMN2NPC1 | |
| SCHEMBL7184746 | 0.76 | TOP2A (0.57) | TERTTOP2AMAOASMN1; SMN2NPC1 | |
| SCHEMBL6408305 | 0.76 | TERT (0.60) | TERTTOP2AKDM4EMAOASMN1; SMN2 | |
| SCHEMBL7189639 | 0.76 | TERT (0.60) | TERTTOP2AKDM4EMAOAMAPT | |
| SCHEMBL7638107 | 0.75 | TOP2A (0.60) | TERTTOP2AKDM4EMAOASMN1; SMN2 | |
| SCHEMBL7186247 | 0.75 | TOP2A (0.75) | TERTTOP2AMAOASMN1; SMN2NPC1 | |
| SCHEMBL6859938 | 0.75 | MAOA (0.40) | TERTTOP2AKDM4EMAOAMAPT | |
| Benzosampangine SCHEMBL20259217 | 0.74 | TOP2A (0.79) | TERTTOP2AMAOASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656948-B2 | Treatment of malignant tumors. | UNIVERSIDAD COMPLUTENSE DE MADRID (ES) | 2003-12-02 | — | — | US | disclosed |
| US-20020128281-A1 | Cytotoxic compounds: derivatives of the pyrido [2,3,4-kl]acridine ring system | UNIVERSIDAD COMPLUTENSE DE MADRID | 2002-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128281-A1 | Cytotoxic compounds: derivatives of the pyrido [2,3,4-kl]acridine ring system | CASP3, NR4A1, CASP4 | TERT 1994/4885TOP2A 81/4885KDM4E 862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.