Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 6/20 | 0.65 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.65 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.65 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.65 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 5/20 | 0.48 |
| ▸ | BRAF | P15056 | 5/20 | 0.48 |
| ▸ | ATR | Q13535 | 3/20 | 0.47 |
| ▸ | ATRIP | Q8WXE1 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7215859 | 0.84 | MAPK13 (0.67) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL7001627 | 0.81 | MAPK13 (0.50) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL7215386 | 0.79 | MAPK11 (0.61) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Hydrochloric Acid SCHEMBL7215092 | 0.78 | MAPK14 (0.98) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Hydrochloric Acid SCHEMBL7215094 | 0.77 | MAPK13 (0.70) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL17590 | 0.76 | KMO (0.59) | NPSR1TP53 | |
| SCHEMBL7676169 | 0.75 | KMO (0.47) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| Hydrochloric Acid SCHEMBL7215096 | 0.75 | MAPK13 (0.63) | MAPK13MAPK12MAPK11MAPK14MAPK9 | |
| SCHEMBL1384726 | 0.73 | TGFBR1 (0.41) | MAPK13MAPK12MAPK11MAPK14NPSR1 | |
| SCHEMBL8485742 | 0.72 | CSNK1A1 (0.44) | MAPK13MAPK12MAPK11MAPK14MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602872-B1 | Substituted pyridazines having cytokine inhibitory activity | MERCK & CO., INC. | 2003-08-05 | — | — | US | disclosed |