SCHEMBL7216

SCHEMBL7216

CCOC(=O)Cc1ccc(-c2ccc(-c3onc(C)c3N(C)CCCc3cccc(Cl)c3)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.41
ALDH1A1 P00352 1/20 0.39
ALOX5 P09917 2/20 0.37
AOC3 Q16853 1/20 0.37
MMEL1 Q495T6 1/20 0.37
L3MBTL1 Q9Y468 3/20 0.36
ALOX15 P16050 1/20 0.36
CRHBP P24387 1/20 0.36
HTT P42858 1/20 0.36
CRHR2 Q13324 1/20 0.36
MAPT P10636 3/20 0.35
TSHR P16473 1/20 0.35
KLK7 P49862 1/20 0.35
LPAR1 Q92633 1/20 0.34
LPAR2 Q9HBW0 1/20 0.34
LPAR3 Q9UBY5 1/20 0.34
MEN1 O00255 1/20 0.34
LMNA P02545 1/20 0.34
HPGD P15428 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8174 0.90 MAOB (0.41) MAOBALOX5HTTLPAR1LMNA
SCHEMBL6857 0.89 LPAR1 (0.42) ALDH1A1AOC3LPAR1LPAR2LPAR3
SCHEMBL6630 0.87 HDAC1 (0.40) ALDH1A1MAPTMEN1KMT2A
SCHEMBL6765 0.86 BRD4 (0.33) MAOBALDH1A1ALOX5AOC3MMEL1
SCHEMBL1568 0.85 KCNA3 (0.39) ALDH1A1AOC3L3MBTL1MAPTTSHR
SCHEMBL6610 0.85 FFAR1 (0.43) ALDH1A1AOC3KMT2ASMN1; SMN2
SCHEMBL1630 0.80 ABCC3 (0.42) AOC3LPAR1MEN1KMT2A
SCHEMBL6543 0.80 HDAC1 (0.40) ALDH1A1ALOX5MAPTMEN1KMT2A
SCHEMBL6150 0.79 BRD4 (0.36) ALDH1A1AOC3
SCHEMBL7466 0.79 LPAR1 (0.47) ALOX5LPAR1LPAR2LPAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed