Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6445 | 0.91 | CHRM1 (0.36) | SLC26A6GAAJAK2JAK1ALDH1A1 | |
| SCHEMBL7572 | 0.91 | SLC26A6 (0.36) | BRD4SLC26A6GAAMAOBALDH1A1 | |
| SCHEMBL6150 | 0.91 | BRD4 (0.36) | BRD4AOC3ALDH1A1 | |
| SCHEMBL11897090 | 0.89 | HDAC1 (0.36) | ALDH1A1SMN1; SMN2KDM4EMEN1LMNA | |
| SCHEMBL1568 | 0.88 | KCNA3 (0.39) | AOC3SLC26A6ALDH1A1KDM4ELMNA | |
| SCHEMBL6153 | 0.87 | GAA (0.36) | BRD4AOC3SLC26A6GAAJAK2 | |
| SCHEMBL7216 | 0.86 | MAOB (0.41) | AOC3MAOBMMEL1ALDH1A1ALOX5 | |
| SCHEMBL7632 | 0.85 | KMT2A (0.38) | GAAALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL7532 | 0.85 | ALOX5 (0.35) | BRD4AOC3GAAALDH1A1ALOX5 | |
| SCHEMBL1630 | 0.84 | ABCC3 (0.42) | BRD4AOC3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |