Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216 | 0.90 | MAOB (0.41) | MAOBLPAR1ALOX5LMNAHTT | |
| SCHEMBL7466 | 0.89 | LPAR1 (0.47) | LPAR1CA12CA1CA2CA5A | |
| SCHEMBL6630 | 0.89 | HDAC1 (0.40) | SYKLTB4R2 | |
| SCHEMBL7572 | 0.86 | SLC26A6 (0.36) | MAOBLPAR1SLC26A6SCD5ALOX5 | |
| SCHEMBL2284 | 0.85 | NPSR1 (0.43) | LPAR1SLC26A6SCD5LMNAHTT | |
| SCHEMBL6543 | 0.82 | HDAC1 (0.40) | SYKALOX5LTB4R2 | |
| SCHEMBL2292 | 0.80 | CYP2C9 (0.42) | LPAR1SCD5ALOX5ALOX5APLMNA | |
| SCHEMBL7297 | 0.79 | SCD5 (0.35) | LPAR1SLC26A6SCD5ALOX5ALOX5AP | |
| SCHEMBL6857 | 0.79 | LPAR1 (0.42) | LPAR1LTB4R2TAAR1BRD4 | |
| SCHEMBL6811 | 0.78 | HDAC1 (0.42) | LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |