Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6765 | 0.91 | BRD4 (0.33) | BRD4AOC3ALDH1A1 | |
| SCHEMBL7297 | 0.90 | SCD5 (0.35) | BRD4TAAR1HSD11B1 | |
| SCHEMBL7148 | 0.90 | ALDH1A1 (0.38) | AOC3ALDH1A1FFAR4 | |
| SCHEMBL1630 | 0.88 | ABCC3 (0.42) | BRD4AOC3TP53TAAR1HIF1A | |
| SCHEMBL6082 | 0.88 | HDAC1 (0.34) | TP53ALDH1A1FFAR4 | |
| SCHEMBL7234 | 0.86 | LPAR1 (0.34) | BRD4AOC3ALDH1A1TAAR1FFAR4 | |
| SCHEMBL6857 | 0.85 | LPAR1 (0.42) | BRD4AOC3TP53ALDH1A1TAAR1 | |
| SCHEMBL6610 | 0.85 | FFAR1 (0.43) | AOC3TP53ALDH1A1FFAR4 | |
| SCHEMBL1568 | 0.85 | KCNA3 (0.39) | AOC3ALDH1A1 | |
| SCHEMBL7294 | 0.85 | P2RX7 (0.36) | FFAR4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |