Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216342 | 0.88 | CA2 (0.52) | L3MBTL1MAPK1NISCHCA2SIRT2 | |
| SCHEMBL1519087 | 0.88 | L3MBTL1 (0.45) | L3MBTL1MAPK1CA2HPGDTSHR | |
| SCHEMBL16413927 | 0.84 | SIRT1 (0.45) | L3MBTL1MAPK1NISCHSIRT2SIRT1 | |
| SCHEMBL21198399 | 0.83 | NISCH (0.45) | NISCHSIRT2SIRT1HPGDALOX5 | |
| SCHEMBL21198653 | 0.81 | NISCH (0.44) | L3MBTL1NISCHSIRT2SIRT1HPGD | |
| SCHEMBL1519389 | 0.80 | L3MBTL1 (0.48) | L3MBTL1MAPK1HPGDTSHRMEN1 | |
| SCHEMBL11482662 | 0.78 | SMN1; SMN2 (0.48) | L3MBTL1HPGDTSHRMEN1KMT2A | |
| SCHEMBL21198704 | 0.77 | NPC1 (0.55) | NISCHSIRT2SIRT1MEN1KMT2A | |
| SCHEMBL30946854 | 0.76 | NISCH (0.71) | L3MBTL1NISCHHPGDALOX5MEN1 | |
| SCHEMBL2977327 | 0.76 | NISCH (0.71) | L3MBTL1NISCHHPGDALOX5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610725-B1 | Alpha 2-adrenergic receptor antagonist and intended in this respect to treat neurodegenerative diseases, | PIERRE FABRE MEDICAMENT (FR) | 2003-08-26 | — | — | US | disclosed |
| EP-1192152-B1 | NOVEL FLUORINATED IMIDAZOLINE BENZODIOXANE, PREPARATION AND THERAPEUTIC USES THEREOF | PF MEDICAMENT (FR) | 2002-11-27 | — | — | EP | disclosed |