Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1519103 | 0.88 | CA2 (0.49) | CA2MAPK1CYP11B1CYP11B2L3MBTL1 | |
| SCHEMBL7216006 | 0.88 | L3MBTL1 (0.45) | CA2SIRT1SIRT2MAPK1NISCH | |
| SCHEMBL8116022 | 0.83 | CHRNB4 (0.47) | SIRT1SIRT2NISCHCYP11B1CYP11B2 | |
| SCHEMBL1519238 | 0.80 | L3MBTL1 (0.46) | CA2MAPK1L3MBTL1KDM4EGAA | |
| SCHEMBL11484736 | 0.78 | HPGD (0.48) | L3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL30946854 | 0.76 | NISCH (0.71) | NISCHL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL2977327 | 0.76 | NISCH (0.71) | NISCHL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL1519087 | 0.75 | L3MBTL1 (0.45) | CA2MAPK1L3MBTL1KDM4EGAA | |
| SCHEMBL16413927 | 0.75 | SIRT1 (0.45) | SIRT1SIRT2MAPK1NISCHCYP11B1 | |
| Hydrochloric Acid SCHEMBL11099585 | 0.75 | NISCH (0.69) | NISCHL3MBTL1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610725-B1 | Alpha 2-adrenergic receptor antagonist and intended in this respect to treat neurodegenerative diseases, | PIERRE FABRE MEDICAMENT (FR) | 2003-08-26 | — | — | US | claimed |
| EP-1192152-B1 | NOVEL FLUORINATED IMIDAZOLINE BENZODIOXANE, PREPARATION AND THERAPEUTIC USES THEREOF | PF MEDICAMENT (FR) | 2002-11-27 | — | — | EP | claimed |
| CN-101372483-A | Method for synthesizing substituted benzo (1,4) dioxane derivative | BEIJING CHARNA CHEMICALS LTD (CN) | 2009-02-25 | — | — | CN | disclosed |
| US-6610725-B1 | Alpha 2-adrenergic receptor antagonist and intended in this respect to treat neurodegenerative diseases, | PIERRE FABRE MEDICAMENT (FR) | 2003-08-26 | — | — | US | disclosed |
| EP-1192152-B1 | NOVEL FLUORINATED IMIDAZOLINE BENZODIOXANE, PREPARATION AND THERAPEUTIC USES THEREOF | PF MEDICAMENT (FR) | 2002-11-27 | — | — | EP | disclosed |
| EP-1192152-A1 | NOVEL FLUORINATED IMIDAZOLINE BENZODIOXANE, PREPARATION AND THERAPEUTIC USES THEREOF | PIERRE FABRE MEDICAMENT (FR) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001000619-A1 | NOVEL FLUORINATED IMIDAZOLINE BENZODIOXANE, PREPARATION AND THERAPEUTIC USES THEREOF | PIERRE FABRE MEDICAMENT (FR) | 2001-01-04 | — | — | WO | disclosed |