Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216711 | 0.80 | ALDH1A1 (0.51) | TDP1ALDH1A1PSMD14CYP3A4TSHR | |
| SCHEMBL29471407 | 0.78 | PI4KA (0.50) | TSHRLMNAPIK3CDPIK3CAPIK3CB | |
| SCHEMBL24640 | 0.78 | PI4KA (0.50) | TSHRLMNAPIK3CDPIK3CAPIK3CB | |
| Ammonia Solution, Strong SCHEMBL28104176 | 0.76 | PI4KA (0.48) | TSHRLMNAPIK3CDPIK3CAPIK3CB | |
| Benzene SCHEMBL28791218 | 0.75 | PI4KA (0.47) | ALDH1A1LMNAPIK3CDPIK3CAPIK3CB | |
| SCHEMBL8467252 | 0.71 | ALDH1A1 (1.00) | TDP1ALDH1A1PSMD14CYP3A4TSHR | |
| SCHEMBL33781 | 0.71 | ALDH1A1 (1.00) | TDP1ALDH1A1PSMD14CYP3A4TSHR | |
| Iodide SCHEMBL5069469 | 0.69 | ALDH1A1 (0.86) | TDP1ALDH1A1PSMD14CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL970320 | 0.69 | ALDH1A1 (0.95) | TDP1ALDH1A1PSMD14CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL970321 | 0.69 | ALDH1A1 (0.95) | TDP1ALDH1A1PSMD14CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339702-A1 | 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-09-03 | — | — | EP | disclosed |
| WO-2001068619-A1 | 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEX INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-20 | — | — | WO | disclosed |