SCHEMBL29471407

SCHEMBL29471407

Nc1ncnc2nn[nH]c12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PI4KA P42356 8/20 0.50
PI4K2B Q8TCG2 8/20 0.50
PI4K2A Q9BTU6 8/20 0.50
PI4KB Q9UBF8 8/20 0.50
XDH P47989 2/20 0.50
LRRK2 Q5S007 2/20 0.50
LMNA P02545 2/20 0.50
DRD3 P35462 1/20 0.50
ADORA2A P29274 1/20 0.46
ADORA1 P30542 1/20 0.46
NUDT1 P36639 2/20 0.42
RET P07949 1/20 0.41
ERAP1 Q9NZ08 1/20 0.41
PIK3CD O00329 3/20 0.36
PIK3CA P42336 3/20 0.36
PIK3CB P42338 3/20 0.36
PIK3CG P48736 3/20 0.36
PRKDC P78527 3/20 0.36
TSHR P16473 2/20 0.36
LIMK1 P53667 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24640 1.00 PI4KA (0.50) PI4KAPI4K2BPI4K2API4KBXDH
Benzene SCHEMBL28791218 0.96 PI4KA (0.47) PI4KAPI4K2BPI4K2API4KBXDH
Purine SCHEMBL28553167 0.80 PI4KA (0.49) PI4KAPI4K2BPI4K2API4KBXDH
SCHEMBL7216713 0.78 TDP1 (0.50) PI4KAPI4K2BPI4K2API4KBXDH
SCHEMBL8652766 0.78 LMNA (0.54) PI4KAPI4K2BPI4K2API4KBXDH
SCHEMBL3445228 0.74 DYRK1A (0.39)
SCHEMBL7644350 0.74
SCHEMBL14322494 0.74 PDPK1 (0.38) XDHLMNA
SCHEMBL5134210 0.68
SCHEMBL30492908 0.68 PTPN11 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 287 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025043082-A2 COMPOSITIONS AND METHODS TO IMPROVE RNA PROPERTIES USING BASE, PHOSPHODIESTER LINKAGE, SUGAR BACKBONE, AND CAP MODIFICATIONS THE BROAD INSTITUTE, INC. (US) 2025-02-27 WO claimed
WO-2025038970-A1 MODIFIED OLIGONUCLEOTIDES CONTAINING MULTIPLE OLIGONUCLEOTIDES ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 WO claimed
WO-2025038960-A1 OLIGONUCLEOTIDES CONTAINING A LIGAND AT AN INTERNAL POSITION ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 WO claimed
WO-2025038971-A1 OLIGONUCLEOTIDES CONTAINING A LIGAND AT A NUCLEOBASE, 2' POSITION, OR 3' POSITION ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 WO claimed
EP-4499835-A2 METHODS OF USING OLIGOMERIC COMPOUNDS TO TREAT SCN2A-RELATED DISORDERS Praxis Precision Medicines, Inc. (US) 2025-02-05 EP claimed
EP-4466074-A1 POLY-TAILED AND POLY-CAPPED MRNA AND USES THEREOF The Broad Institute Inc. (US) 2024-11-27 EP claimed
EP-3419665-B1 TREATMENT METHODS FOR FIBROSIS TARGETING SMOC2 BRIGHAM & WOMENS HOSPITAL INC (US) 2024-10-30 EP claimed
CN-117795071-A Antisense oligonucleotides for preventing renal dysfunction caused by endothelial dysfunction through inhibition of ephrin-B2 马克斯·普朗克科学促进学会 2024-03-29 CN claimed
WO-2023141474-A9 POLY-TAILED AND POLY-CAPPED MRNA AND USES THEREOF THE BROAD INSTITUTE, INC. (US) 2023-10-26 WO claimed
WO-2023192885-A2 METHODS OF USING OLIGOMERIC COMPOUNDS TO TREAT SCN2A-RELATED DISORDERS PRAXIS PRECISION MEDICINES, INC. (US) 2023-10-05 WO claimed
WO-2023141474-A1 POLY-TAILED AND POLY-CAPPED MRNA AND USES THEREOF THE BROAD INSTITUTE, INC. (US) 2023-07-27 WO claimed
CN-114761026-A Compositions and methods for in vivo synthesis of non-native polypeptides 斯克利普斯研究所 2022-07-15 CN claimed
EP-4743577-A1 RNA-EDITING OLIGONUCLEOTIDES AND USES THEREOF Korro Bio, Inc. (US) 2026-05-20 EP disclosed
EP-4739778-A2 RNA MOLECULE Imperial College Innovations Limited (GB) 2026-05-13 EP disclosed
US-20260109976-A1 SYNTHETIC ENGINEERED RNA MOLECULES AND RELATED METHODS RNAV8 BIO INC (US) 2026-04-23 US disclosed
EP-4720338-A1 METHODS OF MAKING BARRIERS INCLUDING NANOPORES AND CROSS-LINKED AMPHIPHILIC MOLECULES, AND BARRIERS FORMED USING SAME Illumina, Inc. (US) 2026-04-08 EP disclosed
EP-3976788-A1 OLIGONUCLEOTIDE THERAPY FOR WOLMAN DISEASE AND CHOLESTERYL ESTER STORAGE DISEASE Deep Genomics Incorporated (CA) 2022-04-06 EP disclosed
EP-3387132-B1 APTAMERS, NUCLEIC ACID MOLECULES, POLYNUCLEOTIDES, SYNTHETIC ANTIBODIES COMPOSITIONS FOR DETECTING PRRS VIRUSES AND TREATING PRRS VIRUS INFECTION AEROVIRUS TECH INC (CA) 2022-04-06 EP disclosed
WO-2022066647-A1 USE OF CRISPR-CAS ENDONUCLEASES FOR PLANT GENOME ENGINEERING INARI AGRICULTURE TECHNOLOGY, INC. (US) 2022-03-31 WO disclosed
WO-2022055726-A1 DETECTING NUCLEIC ACIDS USING SUGAR-LECTIN COUPLINGS ILLUMINA, INC. (US) 2022-03-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260109976-A1 SYNTHETIC ENGINEERED RNA MOLECULES AND RELATED METHODS UPF1, RNGTT, NSUN3 PI4KA 1430/4885PI4K2B 853/4885PI4K2A 1227/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.