Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 14/20 | 0.56 |
| ▸ | CA1 | P00915 | 13/20 | 0.56 |
| ▸ | CA9 | Q16790 | 13/20 | 0.56 |
| ▸ | CA12 | O43570 | 10/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220475 | 0.87 | AKR1C3 (0.51) | PTGS2ALDH1A1KMT2ACYP1A2PTGS1 | |
| SCHEMBL3089210 | 0.87 | ALDH1A1 (0.62) | CA2CA1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL7214638 | 0.84 | CA2 (0.55) | CA2CA1CA9CA12CA14 | |
| SCHEMBL6025710 | 0.81 | MAOA (0.56) | CA2CA1CA9CA12CA14 | |
| SCHEMBL6025295 | 0.81 | CA1 (0.53) | CA2CA1CA9CA12CA14 | |
| SCHEMBL2150940 | 0.81 | ALDH1A1 (0.55) | CA2CA1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL3105019 | 0.81 | ALDH1A1 (0.55) | CA2CA1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL7214803 | 0.80 | PTGS2 (0.51) | CA2CA1CA9CA12CA14 | |
| SCHEMBL7214644 | 0.80 | PTGS2 (0.53) | CA2CA1CA9CA12CA14 | |
| SCHEMBL3092612 | 0.80 | HPGD (0.60) | PTGS2ALDH1A1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670365-B1 | Treatment of inflamation and/or cyclooxygenase-mediated diseases, reduced ulcerogenic effects; 2-phenyl-3-(4-methylsulfonylphenyl)imidazo(1,2-a)pyrimidine | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2003-12-30 | — | — | US | disclosed |
| EP-1104762-B1 | SUBSTITUTED IMIDAZO[1,2A]AZINES AS SELECTIVE INHIBITORS OF COX-2 | S A L V A T LAB SA (ES) | 2002-09-18 | — | — | EP | disclosed |
| EP-1104762-A1 | SUBSTITUTED IMIDAZO 1,2A]AZINES AS SELECTIVE INHIBOTORS OF COX-2 | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2001-06-06 | — | — | EP | disclosed |