Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KDM1A | O60341 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22402969 | 0.90 | SMN1; SMN2 (0.59) | POLBTP53MAPTNPC1RAB9A | |
| SCHEMBL21552129 | 0.90 | SMN1; SMN2 (0.59) | POLBTP53MAPTNPC1RAB9A | |
| SCHEMBL7217283 | 0.89 | POLB (0.59) | POLBTP53MAPTNPC1RAB9A | |
| SCHEMBL28476992 | 0.84 | SMN1; SMN2 (0.51) | POLBMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3980617 | 0.83 | KMT2A (0.55) | POLBMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL180159 | 0.83 | KMT2A (0.55) | POLBMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL979240 | 0.83 | KMT2A (0.55) | POLBMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL15947583 | 0.81 | POLB (0.50) | POLBTP53MAPTNPC1RAB9A | |
| SCHEMBL23917849 | 0.80 | ALDH1A1 (0.69) | POLBTP53MAPTNPC1RAB9A | |
| SCHEMBL592715 | 0.80 | POLB (0.66) | POLBTP53MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531604-B2 | Useful as medicines having an osteogenesis promoting effect and chondrogensis promoting effect. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-03-11 | — | — | US | disclosed |
| US-20020128308-A1 | Benzothiepine derivatives, their production and use | YASUMA TSUNEO (JP) | 2002-09-12 | — | — | US | disclosed |
| US-6355672-B1 | BONE DISORDERS; CENTRAL NERVOUS SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-03-12 | — | — | US | disclosed |
| EP-1103552-A1 | BENZOTHIEPIN DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128308-A1 | Benzothiepine derivatives, their production and use | APP, BMP1, BACE1 | POLB 3851/4885TP53 2752/4885MAPT 331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.