Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17145065 | 0.80 | DPP4 (0.41) | L3MBTL1DPP4 | |
| SCHEMBL507078 | 0.80 | NAAA (0.46) | ALDH1A1MEN1KMT2ANAAALMNA | |
| SCHEMBL9119549 | 0.77 | DHFR (0.31) | L3MBTL1 | |
| SCHEMBL7212889 | 0.77 | KDM4E (0.33) | ALDH1A1LMNA | |
| SCHEMBL7211776 | 0.76 | KDM4C (0.36) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7217804 | 0.75 | NPC1 (0.43) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL7050550 | 0.73 | SIGMAR1 (0.39) | MEN1KMT2A | |
| SCHEMBL12069897 | 0.73 | L3MBTL1 (0.40) | ALDH1A1MEN1KMT2ANAAALMNA | |
| SCHEMBL10058953 | 0.72 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL9123646 | 0.72 | DHFR (0.35) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |