Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.39 |
| ▸ | LTA4H | P09960 | 4/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380531 | 0.91 | L3MBTL1 (0.44) | L3MBTL1MAPTITGB3ITGA2BHTT | |
| SCHEMBL7215538 | 0.89 | SUCNR1 (0.40) | MAPTTHRBNPC1MEN1ALDH1A1 | |
| SCHEMBL7380075 | 0.82 | MAPT (0.39) | L3MBTL1MAPTITGB3ITGA2BSIRT2 | |
| SCHEMBL7217983 | 0.81 | L3MBTL1 (0.53) | L3MBTL1MAPTITGB3ITGA2BHTT | |
| SCHEMBL7217582 | 0.79 | SMN1; SMN2 (0.39) | MAPTITGB3ALDH1A1 | |
| SCHEMBL7222273 | 0.76 | L3MBTL1 (0.53) | L3MBTL1MAPTITGB3ITGA2BHTT | |
| SCHEMBL7146161 | 0.73 | MEN1 (0.48) | L3MBTL1MAPTHSD17B10SIRT2SIRT1 | |
| SCHEMBL6135483 | 0.72 | CASP1 (0.54) | HSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL7379285 | 0.72 | THRB (0.49) | L3MBTL1ITGB3ITGA2BF2F10 | |
| SCHEMBL7304322 | 0.71 | CYP3A4 (0.53) | MAPTHSD17B10SIRT2SIRT1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115724-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | Shire Biochem Inc. (CA) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017197-A1 | QUINOLIZINONES AS INTEGRIN INHIBITORS | BIOCHEM PHARMA INC. (US) | 2000-03-30 | — | — | WO | disclosed |