Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL706276 | 0.75 | NISCH (0.44) | ADRA1DADRA1AADRA1BMEN1LMNA | |
| SCHEMBL31238855 | 0.75 | NISCH (0.44) | ADRA1DADRA1AADRA1BMEN1LMNA | |
| SCHEMBL8204827 | 0.75 | CA2 (0.50) | CA2CYP19A1L3MBTL1MAPK1CYP11B1 | |
| SCHEMBL8204830 | 0.75 | CA2 (0.50) | CA2CYP19A1L3MBTL1MAPK1CYP11B1 | |
| SCHEMBL8125243 | 0.72 | CA2 (0.58) | CA2CYP19A1L3MBTL1MAPK1CYP11B1 | |
| SCHEMBL31205375 | 0.72 | DRD2 (0.39) | KDM4E | |
| SCHEMBL10914944 | 0.72 | DRD2 (0.39) | KDM4E | |
| SCHEMBL27446891 | 0.71 | CA2 (0.47) | CA2CYP19A1L3MBTL1MAPK1CYP11B1 | |
| SCHEMBL7216342 | 0.70 | CA2 (0.52) | CA2L3MBTL1MAPK1CYP11B1CYP11B2 | |
| SCHEMBL1519103 | 0.70 | CA2 (0.49) | CA2CYP19A1L3MBTL1MAPK1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610725-B1 | Alpha 2-adrenergic receptor antagonist and intended in this respect to treat neurodegenerative diseases, | PIERRE FABRE MEDICAMENT (FR) | 2003-08-26 | — | — | US | disclosed |
| EP-1192152-B1 | NOVEL FLUORINATED IMIDAZOLINE BENZODIOXANE, PREPARATION AND THERAPEUTIC USES THEREOF | PF MEDICAMENT (FR) | 2002-11-27 | — | — | EP | disclosed |