Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7218226 | 0.94 | PARP14 (0.34) | PPARDPARP14PARP10MAPTL3MBTL1 | |
| SCHEMBL7216783 | 0.91 | PPARD (0.35) | PPARDPARP14PARP10MAPTL3MBTL1 | |
| SCHEMBL7218091 | 0.89 | PARP10 (0.37) | PARP14PARP10MAPTL3MBTL1TDP1 | |
| SCHEMBL7218062 | 0.88 | MTNR1B (0.32) | PPARDHSD17B10NPSR1 | |
| SCHEMBL7216128 | 0.88 | PARP10 (0.44) | PARP14PARP10MAPTL3MBTL1SPHK2 | |
| SCHEMBL7218123 | 0.86 | PPARD (0.43) | PPARDMAPTL3MBTL1TDP1HSP90AA1 | |
| SCHEMBL7215817 | 0.86 | NPC1 (0.38) | PPARDMAPTL3MBTL1LMNAHSP90AA1 | |
| SCHEMBL7215840 | 0.86 | PPARD (0.37) | PPARDPARP14PARP10L3MBTL1KDM4E | |
| SCHEMBL7218231 | 0.85 | MAPT (0.34) | PPARDPARP14PARP10MAPTL3MBTL1 | |
| SCHEMBL7218076 | 0.84 | S1PR1 (0.36) | PPARDMAPTLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6627651-B1 | Exhibiting preventive and therapeutic effects against HIV infectious diseases wherein R1 is an optionally substituted five- or six-membered ring group; X1 is a free valency or the like; W is a divalent group and inhibitors of HIV (human | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-30 | — | — | US | disclosed |
| EP-1182195-A1 | CYCLIC COMPOUNDS AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-02-27 | — | — | EP | disclosed |