Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 13/20 | 0.40 |
| ▸ | MAOA | P21397 | 5/20 | 0.40 |
| ▸ | LSS | P48449 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7213385 | 0.85 | THRA (0.40) | MAOBMAOA | |
| SCHEMBL6991041 | 0.84 | GPR119 (0.34) | — | |
| SCHEMBL7212195 | 0.82 | LTA4H (0.34) | MAOBMAOALSS | |
| SCHEMBL6992807 | 0.81 | LSS (0.46) | LSS | |
| SCHEMBL6991262 | 0.74 | CREBBP (0.45) | MAOBMAOA | |
| SCHEMBL6143785 | 0.74 | GPR119 (0.39) | — | |
| SCHEMBL6143001 | 0.73 | CHEK2 (0.40) | AURKB | |
| SCHEMBL27824398 | 0.72 | EPHX2 (0.36) | — | |
| Tert-Butyl Formate SCHEMBL27509807 | 0.71 | MAOB (0.45) | MAOBMAOALSS | |
| SCHEMBL6993576 | 0.71 | CYP4A11 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358162-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002050041-A1 | DIHYDROINDOLE AND TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-27 | — | — | WO | disclosed |