Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NT5E | P21589 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28695477 | 0.98 | TSHR (0.53) | TSHRSMN1; SMN2POLBCYP2D6NAPRT | |
| Hydrochloric Acid SCHEMBL27748505 | 0.72 | TSHR (0.89) | TSHRSMN1; SMN2POLBCYP2D6NAPRT | |
| SCHEMBL10337507 | 0.72 | — | — | |
| SCHEMBL30812783 | 0.72 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6NAPRT | |
| Benzene SCHEMBL9751882 | 0.72 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6NAPRT | |
| SCHEMBL30307036 | 0.72 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6NAPRT | |
| SCHEMBL3409457 | 0.72 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6NAPRT | |
| SCHEMBL2509 | 0.72 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6NAPRT | |
| SCHEMBL7997873 | 0.72 | — | — | |
| SCHEMBL597672 | 0.72 | TSHR (1.00) | TSHRSMN1; SMN2POLBCYP2D6NAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582896-B1 | High Dmax (maximum density), a low fog, a good coated surface condition, and less surface defects such as repellency, coating lines or the like. | FUJI PHOTO FILM CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| US-6083680-A | HIGH IN SENSITIVITY AND HIGH IN CONTRAST, AND CAN PROVIDE AN IMAGE LOW IN DMIN BY UV LIGHT, LIGHT-INSENSITIVE ORGANIC SILVER SALT, A LIGHT-SENSITIVE SILVER HALIDE, | FUJI PHOTO FILM CO., LTD. (JP) | 2000-07-04 | — | — | US | disclosed |