Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 19/20 | 0.54 |
| ▸ | ITGA4 | P13612 | 19/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7462016 | 0.92 | KMT2A (0.49) | ITGB1ITGA4RAB9A | |
| SCHEMBL7468370 | 0.92 | KMT2A (0.49) | ITGB1ITGA4RAB9A | |
| SCHEMBL7468356 | 0.90 | KMT2A (0.45) | ITGB1ITGA4RAB9A | |
| SCHEMBL7467419 | 0.90 | NPC1 (0.49) | ITGB1ITGA4NPC1RAB9A | |
| SCHEMBL7213313 | 0.89 | ITGB1 (0.52) | ITGB1ITGA4NPC1RAB9A | |
| SCHEMBL7461667 | 0.88 | ALDH1A1 (0.49) | NPC1RAB9A | |
| SCHEMBL7462350 | 0.86 | NPC1 (0.43) | ITGB1ITGA4NPC1RAB9A | |
| SCHEMBL7464096 | 0.86 | NPC1 (0.43) | ITGB1ITGA4NPC1RAB9A | |
| SCHEMBL7467442 | 0.86 | KMT2A (0.49) | ITGB1ITGA4NPC1 | |
| SCHEMBL7463792 | 0.86 | ITGB1 (0.57) | ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6624152-B2 | Inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention relates to pharmaceutical formulations comprising these compounds and methods of using them for inflammatory and autoimmune diseases | BIOGEN, INC. | 2003-09-23 | — | — | US | claimed |