Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718551 | 0.78 | LMNA (0.51) | DAOLMNAMAPTPOLBMEN1 | |
| SCHEMBL5204992 | 0.76 | DAO (0.47) | DAOLMNAMAPTPOLBMEN1 | |
| SCHEMBL5657114 | 0.73 | OPRM1 (0.45) | DAOOPRM1OPRK1OPRL1CHRM2 | |
| SCHEMBL6793990 | 0.69 | CHRM2 (0.43) | DAOOPRM1OPRK1OPRL1CHRM2 | |
| SCHEMBL3195768 | 0.67 | HTR7 (0.53) | LMNAMEN1CYP1A2KMT2AOPRM1 | |
| SCHEMBL23832547 | 0.67 | LMNA (0.48) | DAOLMNAMAPTPOLBMEN1 | |
| SCHEMBL3195760 | 0.65 | HTR7 (0.48) | LMNAMEN1CYP1A2KMT2AOPRM1 | |
| SCHEMBL29991182 | 0.63 | DAO (0.61) | DAOLMNAMAPTPOLBMEN1 | |
| SCHEMBL981536 | 0.62 | DAO (0.59) | DAOLMNAMAPTPOLBMEN1 | |
| SCHEMBL20620252 | 0.62 | DAO (0.59) | DAOLMNAMAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660751-B1 | Sulfonamide derivatives as 5-HT7 receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-12-09 | — | — | US | disclosed |
| US-4031226-A | ANTIEMETIC, PSYCHOTROPIC | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-06-21 | — | — | US | disclosed |