Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 6/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.50 |
| ▸ | THRA | P10827 | 2/20 | 0.50 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19480454 | 1.00 | TSHR (0.54) | TSHRTHRBPLA2G2ATHRANR5A1 | |
| SCHEMBL6460166 | 0.98 | TSHR (0.51) | TSHRTHRBPLA2G2ATHRANR5A1 | |
| SCHEMBL7225914 | 0.92 | TSHR (0.44) | TSHRTHRBPLA2G2ATHRANR5A1 | |
| SCHEMBL5028320 | 0.86 | ALDH1A1 (0.42) | TSHRTP53NPC1LMNAGAA | |
| SCHEMBL15298486 | 0.84 | PLA2G2A (0.53) | TSHRTHRBPLA2G2ATHRANR5A1 | |
| SCHEMBL19141798 | 0.82 | TSHR (0.56) | TSHRPLA2G2ANR5A1BLMTP53 | |
| SCHEMBL18886699 | 0.81 | PLA2G2A (0.68) | TSHRTHRBPLA2G2ATHRANR5A1 | |
| SCHEMBL9016884 | 0.81 | PLA2G2A (0.68) | TSHRTHRBPLA2G2ATHRANR5A1 | |
| SCHEMBL8644570 | 0.81 | THRB (0.50) | TSHRTHRBPLA2G2ATHRANR5A1 | |
| SCHEMBL20503338 | 0.81 | THRB (0.50) | TSHRTHRBPLA2G2ATHRANR5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576791-B1 | Local anesthetic compounds and uses | THERAVANCE, INC. | 2003-06-10 | — | — | US | disclosed |
| US-6495681-B1 | PRODUCING LOCAL ANESTHESIA OF LONG-DURATION. THE COMPOUNDS OF THIS INVENTION ARE MULTIBINDING COMPOUNDS THAT COMPRISE FROM 2 TO 10 LIGANDS COVALENTLY ATTACHED TO A LINKER OR LINKERS, EACH LIGAND BEING CAPABLE OF BINDING TO A LIGAND BINDING SITE | THERAVANCE INC. | 2002-12-17 | — | — | US | disclosed |
| US-6462034-B1 | MULTIBINDING COMPOUNDS CONTAINING A SYMETRICAL DIAMINOTETRA-ETHERDODECANE RING WITH TWO SECONDARY AMIDE AND ADDITIONAL SUBSTITUENTS; VOLTAGE GATED SODIUM CHANNEL MODULATORS; LONG DURATION | THERAVANCE, INC. | 2002-10-08 | — | — | US | disclosed |
| US-6337423-B1 | BIND TO VOLTAGE-GATED SODIUM ION CHANNELS TO MODULATE ACTIVITY | ADVANCED MEDICINE, INC. | 2002-01-08 | — | — | US | disclosed |
| CN-1295558-A | Novel local anesthetic compounds and uses | ADVANCED MEDICINE INC (US) | 2001-05-16 | — | — | CN | disclosed |
| EP-1066245-A4 | NOVEL LOCAL ANESTHETIC COMPOUNDS AND USES | ADVANCED MEDICINE INC (US) | 2001-01-24 | — | — | EP | disclosed |
| EP-1066245-A1 | NOVEL LOCAL ANESTHETIC COMPOUNDS AND USES | Advanced Medicine, Inc. (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999051565-A9 | NOVEL LOCAL ANESTHETIC COMPOUNDS AND USES | ADVANCED MEDICINE INC (US) | 1999-12-02 | — | — | WO | disclosed |
| WO-1999051565-A1 | NOVEL LOCAL ANESTHETIC COMPOUNDS AND USES | ADVANCED MEDICINE, INC. (US) | 1999-10-14 | — | — | WO | disclosed |