Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6460166 | 0.94 | TSHR (0.51) | TSHRRAB9APDIA6NPC1LTA4H | |
| SCHEMBL19480454 | 0.92 | TSHR (0.54) | TSHRRAB9APDIA6NPC1LTA4H | |
| SCHEMBL7220329 | 0.92 | TSHR (0.54) | TSHRRAB9APDIA6NPC1LTA4H | |
| SCHEMBL5028320 | 0.89 | ALDH1A1 (0.42) | TSHRRAB9AKDM4ENPC1CA12 | |
| SCHEMBL25231418 | 0.82 | TP53 (0.45) | TSHRPDIA6THRATHRBCYP2C19 | |
| SCHEMBL19141233 | 0.81 | CYP1A2 (0.52) | TSHRRAB9AKDM4ENPC1CA12 | |
| SCHEMBL1401588 | 0.80 | TSHR (0.48) | TSHRRAB9AKDM4ENPC1CA12 | |
| SCHEMBL11444520 | 0.80 | SKP2 (0.55) | TSHRRAB9APDIA6KDM4ENPC1 | |
| SCHEMBL6459850 | 0.80 | TP53 (0.47) | TSHRPDIA6THRATHRBCYP2C19 | |
| SCHEMBL5359909 | 0.80 | MAPT (0.45) | TSHRRAB9AKDM4ENPC1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576791-B1 | Local anesthetic compounds and uses | THERAVANCE, INC. | 2003-06-10 | — | — | US | disclosed |
| US-20030044845-A1 | Novel therapeutic agents for membrane transporters | THERAVANCE BIOPHARMA R&D IP, LLC | 2003-03-06 | — | — | US | disclosed |
| US-6495681-B1 | PRODUCING LOCAL ANESTHESIA OF LONG-DURATION. THE COMPOUNDS OF THIS INVENTION ARE MULTIBINDING COMPOUNDS THAT COMPRISE FROM 2 TO 10 LIGANDS COVALENTLY ATTACHED TO A LINKER OR LINKERS, EACH LIGAND BEING CAPABLE OF BINDING TO A LIGAND BINDING SITE | THERAVANCE INC. | 2002-12-17 | — | — | US | disclosed |
| US-6462034-B1 | MULTIBINDING COMPOUNDS CONTAINING A SYMETRICAL DIAMINOTETRA-ETHERDODECANE RING WITH TWO SECONDARY AMIDE AND ADDITIONAL SUBSTITUENTS; VOLTAGE GATED SODIUM CHANNEL MODULATORS; LONG DURATION | THERAVANCE, INC. | 2002-10-08 | — | — | US | disclosed |
| US-6337423-B1 | BIND TO VOLTAGE-GATED SODIUM ION CHANNELS TO MODULATE ACTIVITY | ADVANCED MEDICINE, INC. | 2002-01-08 | — | — | US | disclosed |
| WO-1999064045-A9 | NOVEL THERAPEUTIC AGENTS FOR MEMBRANE TRANSPORTERS | ADVANCED MEDICINE INC (US) | 2001-07-05 | — | — | WO | disclosed |
| CN-1295558-A | Novel local anesthetic compounds and uses | ADVANCED MEDICINE INC (US) | 2001-05-16 | — | — | CN | disclosed |
| EP-1089749-A4 | NOVEL THERAPEUTIC AGENTS FOR MEMBRANE TRANSPORTERS | ADVANCED MEDICINE INC (US) | 2001-04-11 | — | — | EP | disclosed |
| EP-1089749-A1 | NOVEL THERAPEUTIC AGENTS FOR MEMBRANE TRANSPORTERS | Advanced Medicine, Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| EP-1066245-A4 | NOVEL LOCAL ANESTHETIC COMPOUNDS AND USES | ADVANCED MEDICINE INC (US) | 2001-01-24 | — | — | EP | disclosed |
| US-4237068-A | Primary aminoacylanilides | ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) | 1980-12-02 | — | — | US | disclosed |
| US-4233055-A | Quaternary ammonioalkanecarboxylic acid anilides as plant growth influencing agents | CIBA-GEIGY CORPORATION (US) | 1980-11-11 | — | — | US | disclosed |
| US-4218477-A | LONG LASTING ORAL AGENTS | ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) | 1980-08-19 | — | — | US | disclosed |
| US-4141718-A | ANTIGROWTH AGENTS FOR PLANTS | CIBA-GEIGY CORPORATION (US) | 1979-02-27 | — | — | US | disclosed |
| US-4029794-A | SAXITOXIN | ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) | 1977-06-14 | — | — | US | disclosed |
| US-4029793-A | TETRODOXIN OR DESOXYTETRODOXIN | ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) | 1977-06-14 | — | — | US | disclosed |
| US-4022899-A | TETRODOXIN, DESOXYTETRODOXIN, AMINOALKYL BENZOATE | ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) | 1977-05-10 | — | — | US | disclosed |
| US-4001413-A | PHARMACEUTICAL LOCAL ANESTHETIC COMPOSITION EMPLOYING SAXITOXIN | ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) | 1977-01-04 | — | — | US | disclosed |
| US-3966934-A | AMINOACYL ANILIDE AND A TOXIN | ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) | 1976-06-29 | — | — | US | disclosed |
| US-3957996-A | AMINOACYL ANILIDE, SAXITOXIN, ADMINISTERING | ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) | 1976-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030044845-A1 | Novel therapeutic agents for membrane transporters | SLC47A2, SLC8B1, SLC47A1 | TSHR 1308/4885RAB9A 1595/4885PDIA6 904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.