SCHEMBL7220333

SCHEMBL7220333

COC(=O)C(C)Oc1cc([N+](=O)[O-])c(F)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPOX P50336 2/20 0.40
PDK1 Q15118 1/20 0.39
ALDH1A1 P00352 4/20 0.39
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
LMNA P02545 2/20 0.38
POLB P06746 1/20 0.38
TDP1 Q9NUW8 1/20 0.37
NPC1 O15118 1/20 0.37
CYP3A4 P08684 1/20 0.37
GAA P10253 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
KDM4E B2RXH2 1/20 0.37
MAPT P10636 2/20 0.36
HTT P42858 2/20 0.36
XBP1 P17861 1/20 0.36
RAB9A P51151 1/20 0.36
CCR6 P51684 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29278716 0.87 ALDH1A1 (0.43) PPOXPDK1ALDH1A1KMT2AMEN1
SCHEMBL29278717 0.87 ALDH1A1 (0.43) PPOXPDK1ALDH1A1KMT2AMEN1
SCHEMBL9775686 0.82 PDK1 (0.48) PPOXPDK1ALDH1A1KMT2AMEN1
SCHEMBL2030437 0.81 CUL4A (0.42) ALDH1A1KMT2AMEN1L3MBTL1LMNA
SCHEMBL31047089 0.81 NPC1 (0.35) PDK1ALDH1A1KMT2AMEN1LMNA
SCHEMBL13465753 0.79 ALDH1A1 (0.43) PDK1ALDH1A1KMT2AMEN1LMNA
SCHEMBL30806257 0.79 L3MBTL1 (0.48) PDK1ALDH1A1KMT2AMEN1L3MBTL1
Bicarbonate SCHEMBL31047093 0.79 MAPT (0.34) PDK1ALDH1A1KMT2AMEN1LMNA
SCHEMBL8599623 0.79 PPOX (0.42) PPOXALDH1A1KMT2AMEN1L3MBTL1
SCHEMBL10812032 0.78 MEN1 (0.44) PDK1ALDH1A1KMT2AMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117603147-A N-phenyl triazinone derivative and preparation method and application thereof 贵州大学 2024-02-27 CN disclosed
US-6528455-B1 Post or preemergence herbicides such as 3-(4-chloro-2-fluoro -5-(1-methoxycarbonyl-1-vinyloxy)phenyl)-1-methyl-6-trifluoro methyl-2,4-pyrimidinedione BASF AKTIENGESELLSCHAFT (DE) 2003-03-04 US disclosed