Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220553 | 0.75 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL7220148 | 0.73 | KDM4E (0.31) | MAPTSMN1; SMN2KDM4E | |
| SCHEMBL9720612 | 0.61 | CYP3A4 (0.57) | TSHRCYP3A4HPGDPOLBKMT2A | |
| SCHEMBL5599988 | 0.60 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL5600217 | 0.60 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL7221765 | 0.57 | CRHR1 (0.45) | CRHR1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL29127366 | 0.57 | ALDH1A1 (0.40) | MAPTSMN1; SMN2KDM4ETSHRCYP3A4 | |
| SCHEMBL22430527 | 0.56 | CYP11B1 (0.48) | CRHR1MAPTSMN1; SMN2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL29127365 | 0.55 | ALDH1A1 (0.39) | MAPTSMN1; SMN2TSHRCYP3A4HPGD | |
| SCHEMBL22430509 | 0.55 | POLB (0.64) | SMN1; SMN2KDM4ELMNATSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1103553-A2 | Substituted heterocyclic derivatives | Pfizer Products Inc. (US) | 2001-05-30 | — | — | EP | claimed |
| US-6525067-B1 | Corticotropin releasing factor antagonists; such as 1-(2-methyl-8-(2,4,6-trimethyl-phenyl)-quinolin-4-yl)-propan-1-one-oxime | PFIZER INC | 2003-02-25 | — | — | US | disclosed |
| EP-1103553-A2 | Substituted heterocyclic derivatives | Pfizer Products Inc. (US) | 2001-05-30 | — | — | EP | disclosed |