Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 16/20 | 0.68 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.68 |
| ▸ | MMP13 | P45452 | 10/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 10/20 | 0.45 |
| ▸ | MMP7 | P09237 | 8/20 | 0.45 |
| ▸ | MMP2 | P08253 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8521305 | 1.00 | MMP1 (0.68) | MMP1ADAM17MMP13MMP8MMP12 | |
| SCHEMBL7214373 | 0.90 | MMP1 (0.55) | MMP1ADAM17MMP13MMP8MMP12 | |
| SCHEMBL8521079 | 0.90 | MMP1 (0.55) | MMP1ADAM17MMP13MMP8MMP12 | |
| SCHEMBL7220248 | 0.90 | ADAM17 (0.55) | MMP1ADAM17MMP13MMP8MMP12 | |
| SCHEMBL7215199 | 0.87 | ADAM17 (0.52) | MMP1ADAM17 | |
| SCHEMBL7221238 | 0.85 | ADAM17 (0.57) | MMP1ADAM17MMP13MMP8MMP12 | |
| SCHEMBL7220119 | 0.81 | MMP1 (1.00) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL7221296 | 0.81 | MMP1 (1.00) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL7220235 | 0.71 | MMP1 (0.83) | MMP1ADAM17MMP13MMP8MMP3 | |
| SCHEMBL7214512 | 0.71 | MMP1 (0.83) | MMP1ADAM17MMP13MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | claimed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | claimed |
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | disclosed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |