Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.52 |
| ▸ | MMP1 | P03956 | 3/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220248 | 0.89 | ADAM17 (0.55) | ADAM17MMP1NPC1RAB9APOLB | |
| SCHEMBL7220732 | 0.87 | MMP1 (0.68) | ADAM17MMP1 | |
| SCHEMBL8521305 | 0.87 | MMP1 (0.68) | ADAM17MMP1 | |
| SCHEMBL7221238 | 0.81 | ADAM17 (0.57) | ADAM17MMP1NPC1RAB9ALTA4H | |
| SCHEMBL8521079 | 0.77 | MMP1 (0.55) | ADAM17MMP1 | |
| SCHEMBL7214373 | 0.77 | MMP1 (0.55) | ADAM17MMP1 | |
| SCHEMBL7221169 | 0.75 | MMP1 (0.74) | ADAM17MMP1 | |
| SCHEMBL7220119 | 0.69 | MMP1 (1.00) | ADAM17MMP1 | |
| SCHEMBL7221296 | 0.69 | MMP1 (1.00) | ADAM17MMP1 | |
| SCHEMBL4159824 | 0.63 | GPR119 (0.65) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | disclosed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |