Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.55 |
| ▸ | MMP1 | P03956 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP10 | P09238 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220732 | 0.90 | MMP1 (0.68) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL8521305 | 0.90 | MMP1 (0.68) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL7215199 | 0.89 | ADAM17 (0.52) | ADAM17MMP1NPC1RAB9ALTA4H | |
| SCHEMBL7221238 | 0.85 | ADAM17 (0.57) | ADAM17MMP1NPC1RAB9ALTA4H | |
| SCHEMBL8521079 | 0.84 | MMP1 (0.55) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL7214373 | 0.84 | MMP1 (0.55) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL7216567 | 0.73 | MMP1 (0.80) | ADAM17MMP1MMP2MMP3MMP8 | |
| SCHEMBL7221296 | 0.71 | MMP1 (1.00) | ADAM17MMP1MMP3MMP8MMP13 | |
| SCHEMBL7220119 | 0.71 | MMP1 (1.00) | ADAM17MMP1MMP3MMP8MMP13 | |
| SCHEMBL8216398 | 0.69 | MMP1 (0.64) | ADAM17MMP1MMP2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599890-B1 | Inhibitors of matrix metalloproteinases or the production of tumor necrosis factor | PFIZER INC | 2003-07-29 | — | — | US | disclosed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |