Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7751590 | 0.94 | MEP1B (0.53) | MEP1BAKR1C3L3MBTL1MAPTALDH1A1 | |
| SCHEMBL11107020 | 0.89 | AKR1C3 (0.60) | MEP1BAKR1C3L3MBTL1MAPTALDH1A1 | |
| SCHEMBL7756199 | 0.88 | MEP1B (0.56) | MEP1BAKR1C3L3MBTL1MAPTALDH1A1 | |
| SCHEMBL10461985 | 0.87 | AKR1C3 (0.58) | MEP1BAKR1C3L3MBTL1MAPTALDH1A1 | |
| SCHEMBL3199069 | 0.84 | ATM (0.64) | MEP1BAKR1C3L3MBTL1MAPTALDH1A1 | |
| SCHEMBL2705227 | 0.83 | ALDH1A1 (0.56) | ALDH1A1LMNASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL7402207 | 0.82 | MEP1B (0.65) | MEP1BAKR1C3ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL15372683 | 0.80 | MAPT (0.44) | L3MBTL1MAPTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL30099024 | 0.80 | MEP1B (0.64) | MEP1BAKR1C3L3MBTL1MAPTALDH1A1 | |
| SCHEMBL2678034 | 0.80 | ALDH1A1 (0.62) | MEP1BAKR1C3L3MBTL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525074-B2 | Peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras | MERCK & CO., INC. | 2003-02-25 | — | — | US | disclosed |
| US-20020049217-A1 | Inhibitors of prenyl-protein transferase | MERCK SHARP & DOHME CORP. | 2002-04-25 | — | — | US | disclosed |
| US-6350755-B1 | PEPTIDOMIMETIC COMPOUNDS THAT DO NOT HAVE A THIOL MOIETY; THERAPY OF ARTERIOSCLEROSIS AND DIABETIC VASCULAR PATHOLOGIES; | MERCK & CO., INC. | 2002-02-26 | — | — | US | disclosed |
| WO-2001051128-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-07-19 | — | — | WO | disclosed |
| WO-2001051126-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049217-A1 | Inhibitors of prenyl-protein transferase | FNTA, KRAS, NRAS | MEP1B 269/4885AKR1C3 1736/4885L3MBTL1 1868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.