Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | BTN3A1 | O00481 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | OGG1 | O15527 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 4/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027272 | 0.81 | HTT (0.50) | HTTALDH1A1KDM4EHSD17B10BTN3A1 | |
| SCHEMBL29510856 | 0.74 | HTT (0.50) | HTTALDH1A1KDM4EHSD17B10BTN3A1 | |
| SCHEMBL719618 | 0.74 | HTT (0.50) | HTTALDH1A1KDM4EHSD17B10BTN3A1 | |
| SCHEMBL11792605 | 0.74 | KCNA3 (0.46) | HTTALDH1A1KDM4EHSD17B10BTN3A1 | |
| SCHEMBL11791487 | 0.74 | LMNA (0.51) | HTTALDH1A1KDM4EHSD17B10BTN3A1 | |
| SCHEMBL12250929 | 0.73 | HTR1B (0.55) | ALDH1A1KDM4EHSD17B10HPGDKCNA3 | |
| SCHEMBL17786776 | 0.72 | ALDH1A1 (0.47) | HTTALDH1A1KDM4EHSD17B10BTN3A1 | |
| SCHEMBL1027274 | 0.72 | HTT (0.48) | HTTALDH1A1KDM4EHSD17B10BTN3A1 | |
| SCHEMBL1274249 | 0.72 | HTR1B (0.44) | HTTALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL723907 | 0.71 | HTT (0.41) | HTTALDH1A1KDM4EHSD17B10BTN3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120052046-A1 | Phosphoramidate Derivatives of Guanosine Nucleoside Compunds for Treatment of Viral Infections | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120052046-A1 | Phosphoramidate Derivatives of Guanosine Nucleoside Compunds for Treatment of Viral Infections | PNP, SAMHD1, MTAP | HTT 2589/4885ALDH1A1 4139/4885KDM4E 4140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.