Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1612361 | 0.80 | SKP2 (0.39) | ALDH1A1ESR1ESR2POLBLMNA | |
| SCHEMBL17372947 | 0.80 | ESR1 (0.37) | ESR1ESR2 | |
| SCHEMBL5351500 | 0.79 | ALDH1A1 (0.40) | ALDH1A1ESR1ESR2POLBLMNA | |
| SCHEMBL3764973 | 0.78 | SLC6A2 (0.44) | ESR1ESR2 | |
| SCHEMBL27829497 | 0.78 | ESR1 (0.68) | ALDH1A1ESR1ESR2MAPTCYP1A2 | |
| SCHEMBL3753927 | 0.78 | S1PR1 (0.38) | ESR1ESR2MEN1KMT2ANPC1 | |
| SCHEMBL14722505 | 0.78 | SKP2 (0.57) | ALDH1A1ESR1ESR2POLBMEN1 | |
| SCHEMBL4429458 | 0.78 | DAO (0.44) | ALDH1A1LMNAMEN1KMT2ANPC1 | |
| SCHEMBL3763570 | 0.78 | CYP3A4 (0.46) | ALDH1A1LMNAHTTL3MBTL1MEN1 | |
| SCHEMBL311370 | 0.78 | PTGS1 (0.45) | ALDH1A1ESR1ESR2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100323953-A1 | MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS | PHENOMIX CORPORATION (US) | 2010-12-23 | — | — | US | claimed |
| EP-2111227-A1 | MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS | Phenomix Corporation (US) | 2009-10-28 | — | — | EP | claimed |
| WO-2008086161-A1 | MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS | PHENOMIX CORPORATION (US) | 2008-07-17 | — | — | WO | claimed |
| US-7304086-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2007-12-04 | — | — | US | claimed |
| US-7067553-B2 | Thiourea compounds and the pharmaceutical compositions containing the same | PACIFIC CORPORATION (KR) | 2006-06-27 | — | — | US | claimed |
| EP-1311478-B1 | NOVEL (THIO)UREA COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORP (KR) | 2006-06-07 | — | — | EP | claimed |
| EP-1311478-A4 | NOVEL THIOUREA COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORP (KR) | 2004-08-04 | — | — | EP | claimed |
| US-20030212140-A1 | Novel thiourea compounds and the pharmaceutical compositions containing the same | PACIFIC CORPORATION (KR) | 2003-11-13 | — | — | US | claimed |
| EP-1311478-A1 | NOVEL THIOUREA COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORPORATION (KR) | 2003-05-21 | — | — | EP | claimed |
| WO-2002016319-A1 | NOVEL THIOUREA COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | PACIFIC CORPORATION (KR) | 2002-02-28 | — | — | WO | claimed |
| EP-4156936-A1 | ACTIVE COMPOUND COMBINATIONS | Bayer Aktiengesellschaft (DE) | 2023-04-05 | — | — | EP | disclosed |
| WO-2021239766-A1 | ACTIVE COMPOUND COMBINATIONS | BAYER AKTIENGESELLSCHAFT (DE) | 2021-12-02 | — | — | WO | disclosed |
| CN-104276564-B | A kind of application of carbonization microsphere | 苏州纳微科技有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-102659966-B | The preparation method of a kind of polymer microsphere and application thereof | 苏州纳微科技有限公司 | 2016-07-06 | — | — | CN | disclosed |
| US-20150272947-A1 | INHIBITORS OF PROTEIN KINASES | ASTRAZENECA AB (SE) | 2015-10-01 | — | — | US | disclosed |
| US-4663323-A | Tetrazole derivatives, anti-ulcer composition containing the same and method for treating ulcers | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-05-05 | — | — | US | disclosed |
| EP-0035046-B1 | NOVEL TETRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND ANTI-ULCER COMPOSITION CONTAINING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1985-10-02 | — | — | EP | disclosed |
| US-4540703-A | Tetrazole derivatives, anti-ulcer composition containing the same and method for treating ulcers | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1985-09-10 | — | — | US | disclosed |
| US-4415572-A | CARDIOTONIC AND INOTROPIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-15 | — | — | US | disclosed |
| EP-0035046-A1 | Novel tetrazole derivatives, process for the preparation thereof, and anti-ulcer composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1981-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150272947-A1 | INHIBITORS OF PROTEIN KINASES | CDK1, CDK2, CDK3 | ALDH1A1 2914/4885ESR1 1827/4885ESR2 1403/4885 |
| US-20100323953-A1 | MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS | CTSC, HAVCR2, TMPRSS15 | ALDH1A1 3036/4885ESR1 4100/4885ESR2 3706/4885 |
| US-20030212140-A1 | Novel thiourea compounds and the pharmaceutical compositions containing the same | TRPV1, TRPA1, TAS2R5 | ALDH1A1 2101/4885ESR1 2434/4885ESR2 2047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.